China Tris Base CAS 77-86-1 Factories, Products

Chemical Name:Tris Base

CAS No.: 77-86-1

Molecular Formula:C4H11NO3

Molecular Structure:

 

 

Molecular Weight:121.14

Appearance:White crystal powder

Sample:Free samples are available

Assay: 99.5%

Product Description

Typical Properties

Item Specifications
Content 99.5%—101.0%
Moisture (by karl fischer) ≤0.3%
Insolubles ≤0.005%
PH(5%) 10.0-11.5
UV Absorbance (290nm,40%) ≤0.2
UV Absorbance (400nm 40%) ≤0.2
Heavy metals (as pb) ≤5ppm
Fe ≤5ppm
Cl ≤3ppm
Solubility (1.0M solution in water) Immediately soluble yielding a clear haze-free solution free of particulates
Residue on ignition ≤0.05%
Melting point(°C) 168.0-172.0
Appearance White crystal powder

Applications

1. Biological Buffers

Molecular Biology: DNA/RNA extraction, agarose gel electrophoresis (TAE/TBE buffers).

Protein Biochemistry: Enzyme activity assays, protein purification, ELISA, and chromatography eluents.

Cell Culture: Maintains stable pH in culture media, compatible with the physiological pH range of 7–9.

Advantages: No calcium/magnesium precipitation (compared to phosphate buffers), excellent compatibility, and high cost-performance.

2. Pharmaceutical Field

Acid-Base Regulator (Tromethamine): Corrects metabolic/respiratory acidosis; penetrates cell membranes without increasing COψ retention.

Pharmaceutical Excipient: pH stabilizer for injections (e.g., Iopromide) and lyophilized preparations.

Pharmaceutical Intermediate: Used in the synthesis of antibacterial drugs, local anesthetics, and contrast agents.

3. Cosmetics & Daily Chemicals

pH Adjuster: Provides gentle pH stabilization for lotions, creams, serums, and shampoos, reducing irritation.

Stabilizer: Improves formulation stability and extends shelf life.

4. Industrial Applications

Coatings / Inks: pH adjuster, dispersant, and anti-settling agent.

Surfactants: Synthesis of non-ionic surfactants and emulsifiers.

Rubber Auxiliaries: Vulcanization accelerator and antioxidant intermediate.

Water Treatment: Heavy metal chelating agent and pH regulator.

Package

25kg/drum

Storage

Store in a cool, dry place; keep sealed and protected from moisture.

Frequently Asked Questions (FAQ)

Q: What is the purity level and appearance of this product?

The product offers a high purity content between 99.5% and 101.0%, and it comes as a white crystal powder.

Q: How is the product used in biological buffers?

It is widely utilized in molecular biology (such as TAE/TBE buffers for DNA/RNA extraction), protein biochemistry (ELISA, enzyme assays, protein purification), and cell culture media to maintain a stable physiological pH of 7–9.

Q: What role does Tromethamine play in pharmaceutical formulations?

It serves as an acid-base regulator to correct acidosis, a pH stabilizer in injectable and lyophilized preparations, and a crucial chemical intermediate for local anesthetics and contrast agents.

Q: Is this compound suitable for cosmetics and personal care products?

Yes, it acts as a gentle pH adjuster and stabilizer for creams, lotions, serums, and shampoos, helping reduce irritation and extend formulation shelf life.

Q: What are the primary packaging options?

The standard packaging for this product is 25kg per drum, ensuring safe transport and handling.

Q: What are the recommended storage conditions?

It should be stored in a cool, dry place and kept tightly sealed to protect the powder from moisture.

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