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Tris(hydroxymethyl)aminomethane, universally designated by its CAS registration number 77-86-1 and chemically identified as Tromethamine or Tris Base, represents a foundational primary amine organic compound. Engineered with three hydrophilic hydroxymethyl groups attached to a central carbon core, CAS 77-86-1 possesses exceptional buffering performance within the physiological pH range of 7.0 to 9.0 at 25°C.
As a leading China CAS 77-86-1 supplier & factory, JIMPOCHEM enforces rigorous batch consistency for both industrial and ultra-pure bio-pharmaceutical grades. Below are the standard physicochemical properties verified through state-of-the-art analytical testing:
| Parameter | Standard Specification Value |
|---|---|
| Chemical Name | Tris(hydroxymethyl)aminomethane / Tromethamine |
| CAS Registry Number | 77-86-1 |
| Molecular Formula / Weight | C4H11NO3 / 121.14 g/mol |
| Assay (Purity on Dry Basis) | ≥ 99.9% (Titration / HPLC) |
| Appearance | White Crystalline Powder / Free-flowing Crystals |
| Melting Point Range | 168.0 °C to 172.0 °C |
| pH (1M Aqueous Solution at 25°C) | 10.3 – 10.7 |
| Effective Buffering Range | pH 7.0 – pH 9.0 |
| Heavy Metals (as Pb) | ≤ 1 ppm (Biotech Grade) / ≤ 5 ppm (Industrial Grade) |
| Bacterial Endotoxins | < 0.03 EU/mg (Ultra-Pure Bio-USP Grade) |
The chemical manufacturing process of CAS 77-86-1 involves the condensation of nitromethane with formaldehyde to yield tris(hydroxymethyl)nitromethane (TN), followed by catalytic hydrogenation over Raney nickel or noble metal catalysts:
Information Gain & Technical Insight: Unlike standard industrial grades that may retain trace nitromethane or catalytic heavy metals, our factory utilizes an advanced multi-stage crystallization process combined with ion-exchange purification. This ensures low UV absorption at 260nm and 280nm (≤0.02 AU), zero nucleolytic activity (DNase/RNase free), and minimal copper/iron interference critical for sensitive biochemical reactions and cell culture formulations.
JIMPOCHEM CO., LTD was established in 2010 and is headquartered in the chemical industry core of Jinan City, Shandong Province. Spanning an expanse of over 500 acres, we are a professional chemical raw material manufacturer integrating advanced research and development, smart production, global supply chain sales, and dedicated technical services.
Our core focus centers on high-end fine chemicals, biopharmaceutical buffers, and cosmetic raw materials. We have earned ISO 9001 quality system certifications, ISO 14001 environmental management system accreditations, and full EU REACH compliance, positioning us as a trusted one-stop chemical solution provider.
Why international chemical purchasers and pharmaceutical giants source CAS 77-86-1 directly from our Shandong production complex.
Situated in Jinan's premier Chemical Industry Park, our facility benefits from direct pipeline integration with upstream raw material suppliers (nitromethane and formaldehyde). This backward integration insulates global partners from raw material market volatility, assuring continuous supply even during global supply chain disruptions.
Operating high-capacity automated continuous crystallization systems enables low unit-cost structures without compromising quality. We pass these operational efficiencies directly to global buyers, offering high-purity Tris Base at factory-direct pricing for long-term contract procurement.
Our modern synthesis units employ Distributed Control Systems (DCS) and SCADA automation to manage reaction temperatures, pH balance, and crystallization cooling curves in real time. This digital control eliminates human error and ensures identical batch-to-batch chemical profiles.
Procuring CAS 77-86-1 for biopharmaceutical, diagnostic, or cosmetic manufacturing requires rigorous regulatory compliance. JIMPOCHEM serves as a turnkey supplier satisfying strict international documentation and quality assurance standards.
Adhering to the core philosophy that "Quality is the lifeline of an enterprise," JIMPOCHEM operates an end-to-end analytical laboratory equipped with Agilent HPLC, Gas Chromatography (GC), ICP-MS heavy metal analyzers, and TOC counters.
Aligning with global "Dual-Carbon" decarbonization commitments and environmental stewardship standards, our factory has invested heavily in green chemical engineering:
Tris Base (CAS 77-86-1) functions as a fundamental reagent across diverse industrial, biological, and cosmetic sectors.
Used as a stabilizer buffer in mRNA vaccines, injectable drug formulations, protein purification (chromatography eluents), and intravenous tromethamine solutions to correct metabolic acidosis.
Essential constituent for TAE (Tris-Acetate-EDTA) and TBE (Tris-Borate-EDTA) electrophoresis buffers, TE buffer for DNA/RNA storage, and tris-buffered saline (TBS) in Western blotting.
Acts as a mild, non-irritating neutralizing agent and pH buffer in personal care creams, anti-aging serums, sunscreens, and hair care formulations, enhancing emulsification stability.
Functions as a chemical intermediate for surfactants, vulcanization accelerators, polyurethane catalysts, and synthetic resin modification, enhancing heat resistance and mechanical strength.
The global biological buffer market, centered around CAS 77-86-1, is experiencing unprecedented expansion driven by breakthroughs in nucleic acid therapies, cell-and-gene therapies (CGT), and point-of-care IVD diagnostic platforms. key industry trends shape global demand:
Our technical team provides one-on-one dedicated technical service tailored to the specific needs of clients across different industries and application scenarios. From product selection and formulation adjustments to custom buffer blend preparation, we build bespoke solutions that optimize your manufacturing efficiency.
Vision: To become a leading global provider of chemical solutions, driving technological innovation and sustainable green development in the industry.
Take a visual tour inside our 500-acre modern chemical manufacturing complex, analytical R&D laboratories, and warehousing facilities.
Answers to critical technical, quality control, and logistics questions regarding CAS 77-86-1 procurement.
We manufacture three specialized grades to meet exact customer specifications: (1) Industrial Grade (≥99.0%) for resin synthesis and chemical processing; (2) Cosmetic/Personal Care Grade (≥99.5%) featuring low odor and controlled trace metals; and (3) Ultra-Pure Bio-Pharmaceutical / Molecular Biology Grade (≥99.9%) certified as DNase/RNase/Protease-free with endotoxin levels controlled to <0.03 EU/mg.
Tris Base (CAS 77-86-1) is the free amine form with a basic aqueous pH (~10.5), whereas Tris HCl (CAS 1185-53-1) is the pre-neutralized hydrochloride salt with an acidic pH (~4.5–5.0). Biochemists frequently combine Tris Base and Tris HCl in specific molar ratios to achieve precise buffer pH values without adding extraneous hydrochloric acid or sodium hydroxide ions.
Every shipment includes a lot-specific Certificate of Analysis (COA), Safety Data Sheet (SDS) compliant with GHS/OSHA standards, REACH registration confirmation for European imports, Country of Origin certificate, ISO compliance verification, and BSE/TSE transmissible spongiform encephalopathy clearance documentation.
Because Tris Base is hygroscopic, our standard export packaging consists of 25 kg heavy-duty fiber drums or double PE-lined moisture-proof kraft paper bags. For ultra-pure biopharma grades, we utilize aluminum foil vacuum bags or sealed plastic drums containing desiccant sachets. Bulk supersacks (500 kg to 1,000 kg) are also available upon request.
Thanks to our 500-acre manufacturing site and steady inventory buffers, standard order fulfillment times are 7 to 10 business days from order confirmation to Qingdao or Shanghai port dispatch. Air freight samples and express courier orders ship within 24 to 48 hours.
Yes, our R&D center provides custom liquid buffer concentrates (e.g., 10x or 50x TAE/TBE/TBS stock solutions), customized particle size milling (micronized Tris), and custom salt formulation services tailored to your proprietary industrial or diagnostic kits.
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