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Comprehensive evaluation of chemical properties, biocidal mechanisms, and synthesis purity standards for global manufacturing.
4-Isopropyl-3-methylphenol (CAS Numbers: 3228-02-2 / 39660-61-2), commonly referred to in international cosmetic indices as O-Cymen-5-ol or IPMP, is a crystalline phenolic isomer of thymol. Possessing an empirical molecular formula of C10H14O and a molecular mass of 150.22 g/mol, IPMP has established itself as an indispensable broad-spectrum antimicrobial biocide across personal care, oral care, dermatological therapeutics, and industrial preservation systems.
Unlike halogenated anti-bacterial additives such as Triclosan or Chloroxylenol (PCMX), 4-Isopropyl-3-methylphenol offers an exceptional safety profile, near-zero odor contribution, minimal color impact on formulations, and non-corrosive characteristics. Its distinct structural positioning of the isopropyl and methyl groups relative to the hydroxyl ring confers superior cell membrane penetration against Gram-positive bacteria, Gram-negative pathogens, yeasts, and dermatophytic fungi.
| Parametric Test | Standard Specification | Analytical Method |
|---|---|---|
| Chemical Assay (HPLC) | ≥ 99.9% Purity | HPLC-UV Peak Area % |
| Appearance | White to Off-White Crystals | Visual Inspection |
| Melting Point | 110.0 °C – 113.0 °C | Capillary Melting Apparatus |
| Boiling Point | 244.0 °C ± 2.0 °C | ASTM D1078 |
| Loss on Drying | ≤ 0.30% | 105°C, 2 Hours |
| Residue on Ignition | ≤ 0.05% | Gravimetric Analysis |
| Heavy Metals (as Pb) | ≤ 10 ppm | ICP-MS Quantitative |
| Chlorinated Phenols | Not Detected (< 1 ppm) | GC-MS Trace Analysis |
Leading China Chemical Raw Material Manufacturer & Designated Global Chemical Service Provider
Established in 2010, JIMPOCHEM CO., LTD is headquartered within the state-certified Chemical Industry Park of Jinan City, Shandong Province, China. Spanning a modern manufacturing footprints exceeding 500 acres, JIMPOCHEM functions as an integrated high-tech enterprise fusing advanced R&D, continuous flow synthesis, automated mass production, global sales, and application technical support.
Our core manufacturing focus spans high-end fine chemicals, active pharmaceutical intermediates, and high-purity cosmetic raw materials. With complete adherence to international governance standards, we operate under dual ISO 9001 Quality Management System and ISO 14001 Environmental Management System accreditations. Our technical team comprises industry veterans with more than 16 years of chemical synthesis expertise, enabling custom synthesis, batch optimization, and rigorous purity guarantee for global multi-nationals.
Core Corporate Commitment: Adhering to the values of "Integrity, Innovation, Professionalism, and Win-Win Cooperation," JIMPOCHEM acts as a trusted supply-chain pillar for over 5,000 international companies across 200+ countries.
Years Industry Leadership
Acres Production Base
Global Export Destinations
Enterprise Clients Worldwide
Transitioning from traditional Friedel-Crafts alkylation to continuous microfluidic synthesis and zero-discharge green chemistry.
Traditional batch reactors for 4-Isopropyl-3-methylphenol synthesis often suffer from localized overheating, leading to unwanted by-products like di-isopropyl isomers. JIMPOCHEM’s modern route utilizes automated microfluidic micro-reactors. This precise thermodynamic control ensures >99.9% conversion efficiency while lowering energy consumption by 32%.
To comply with stringent EU REACH and international cosmetics standards, our purification technology has evolved to a solvent-free fractional crystallization process. By eliminating trace aromatic organic solvents (such as benzene or toluene residue), our final IPMP crystals achieve zero halogen residual and satisfy ultra-pure pharmaceutical requirements.
In response to global "Dual-Carbon" initiatives, JIMPOCHEM’s Jinan production complex integrates waste-heat recovery loops and continuous catalytic regeneration. By recycling unreacted m-cresol and propylene building blocks, our process footprint yields an industry-leading low E-factor (Environmental Factor), guaranteeing sustainable supply security.
Delivering targeted antimicrobial efficacy, skin compatibility, and formulation stability across diverse global sectors.
Acts as an exceptionally mild antibacterial agent and preservative booster in anti-acne cleansers, body washes, deodorants, and facial creams. Effective at concentrations between 0.05% to 0.1%, inhibiting Propionibacterium acnes without disrupting beneficial skin microflora.
Widely adopted in therapeutic toothpastes, mouthwashes, and oral sprays. IPMP penetrates bacterial biofilm matrices to eliminate Streptococcus mutans and Porphyromonas gingivalis, combating plaque formation and bad breath while remaining non-irritating to oral mucosa.
Utilized as an active active ingredient in topical antifungal ointments, medical skin cleansers, hand sanitizers, and surgical disinfectant wipes. Offers broad stability across a pH range of 3.0 to 10.0 and heat tolerance up to 250°C during thermal manufacturing processing.
Engineered into high-performance coatings, rubber seals, industrial plastics, and cleanroom sanitizing agents. Prevents bio-fouling, fungal degradation, and microbial slime growth in humid environments without releasing volatile halogenated byproducts.
Combining raw material integration, smart automation, and rigorous testing for seamless procurement fulfillment.
Located in the heart of Shandong’s petrochemical complex, JIMPOCHEM maintains strategic direct pipeline connections for fundamental feedstocks such as m-cresol and propylene. This vertical consolidation buffers our global procurement partners from volatile international raw material price swings and guarantees uninterrupted production capacity even during global supply shocks.
Our modern plant operates under a centralized Distributed Control System (DCS) linked to Real-Time Process Analytical Technology (PAT). Every synthesis parameter—including temperature, pressure, reaction stoichiometry, and crystallizer cooling rates—is continuously logged, eliminating human error and ensuring unmatched batch-to-batch consistency.
Each drum of 4-Isopropyl-3-methylphenol shipped from our facility bears a unique barcode tied to our LIMS (Laboratory Information Management System). Customers can instantly access raw material origin, in-process analytical data, full COA spectra, and shipment thermal tracking logs, securing seamless customs clearance worldwide.
Supporting international B2B buyers with comprehensive regulatory dossiers, safety documentation, and flexible logistics.
Navigating global regulatory landscapes requires meticulous analytical documentation. JIMPOCHEM provides international buyers with complete technical dossiers to ensure smooth regulatory approvals:
To cater to both R&D trial batches and high-volume commercial production, we offer versatile export packaging configurations backed by robust ocean, air, and multimodal logistics freight connections:
Scientific comparison demonstrating why 4-Isopropyl-3-methylphenol is replacing legacy antimicrobial agents.
| Antimicrobial Parameter | 4-Isopropyl-3-methylphenol (IPMP) | Triclosan (Discontinued in many regions) | Chloroxylenol (PCMX) | Benzalkonium Chloride (BKC) |
|---|---|---|---|---|
| CAS Number | 3228-02-2 / 39660-61-2 | 3380-34-5 | 88-04-0 | 8001-54-5 |
| MIC against S. aureus | 0.01% – 0.02% | 0.003% | 0.05% | 0.01% |
| MIC against P. acnes | 0.005% – 0.01% | 0.01% | 0.08% | 0.03% |
| Odor & Skin Irritation | Odorless / Extremely Mild | Moderate Odor / High Eco-Toxicity | Pungent Phenolic Odor / Irritating | Minimal Odor / Cationic Sensitizer |
| Thermal & pH Stability | Stable to 250°C; pH 3 - 10 | Decomposes under UV/Heat | Stable; pH sensitive | Incompatible with Anionic Surfactants |
| Regulatory Profile | Globally Approved (EU, USA, JP, CN) | Banned in many personal care uses | Restricted in leave-on cosmetics | Restricted dosage in leave-ons |
Expert answers to critical chemical handling, formulation solubility, and procurement inquiries.
IPMP (O-Cymen-5-ol) provides comparable broad-spectrum bactericidal potency at low active doses while offering vastly improved dermatological safety, zero halogenated bio-accumulation risk, no unpleasant medicinal odor, and seamless compatibility with both cationic and anionic surfactant systems.
While 4-Isopropyl-3-methylphenol exhibits low solubility in pure water (~0.27 g/L at 20°C), it is readily soluble in organic solvents such as ethanol, propanol, propylene glycol, and liquid cosmetic oils (e.g., Isopropyl Myristate). In aqueous cosmetic or oral care formulations, it can easily be pre-dissolved in non-ionic surfactants, glycols, or ethanol prior to water phase incorporation.
For anti-acne formulations, oral rinses, and facial cleansers, typical usage concentrations range from 0.05% to 0.1%. As a general cosmetic preservative, dosages between 0.01% and 0.1% are standard, adhering to maximum regulatory limits (e.g., EU Annex V permits up to 0.1% in leave-on and rinse-off products).
Every single batch undergoes full high-performance liquid chromatography (HPLC) testing, gas chromatography-mass spectrometry (GC-MS) for trace chlorophenol identification, melting point verification, and heavy metal testing via ICP-MS. A certified COA accompanies every shipment.
Standard export orders are processed and ready for port loading within 7 to 10 working days. We support FOB, CFR, CIF, DDP, and DAP terms via major Chinese sea ports (Qingdao, Shanghai, Tianjin) with full container load (FCL) or less-than-container load (LCL) options.
A visual tour of JIMPOCHEM’s 500+ acre industrial base, testing laboratories, packaging lines, and partner networks.
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