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In the fine chemical synthesis and advanced material sectors, 5-Xylenol (chemically designated as 3,5-dimethylphenol or 3,5-xylenol, CAS Registry Number 108-68-9) stands out as an irreplaceable structural building block. Characterized by its symmetrical 3,5-dimethyl substitution on the phenolic ring, 5-xylenol possesses unique steric and electronic attributes that make it superior to other xylenol isomers (such as 2,6-xylenol, 2,4-xylenol, or 3,4-xylenol) when synthesizing high-performance antioxidants, antimicrobial agents, specialty resins, and agrochemical active ingredients.
When procurement directors and chemical formulation engineers seek to buy 5-xylenol from certified global manufacturers, evaluating isomeric purity, trace phenolic contaminant profiles, and thermal stability is critical. Pure 3,5-xylenol presents as white to light-yellow crystalline needle structures or molten liquid depending on temperature, featuring a distinctive phenolic odor and low solubility in water, but complete miscibility in alcohols, ethers, and organic aromatic solvents.
| Property Parameter | Technical Grade Specification | High-Purity / Pharma Grade Specification | Testing Standard / Method |
|---|---|---|---|
| CAS Registry Number | 108-68-9 | 108-68-9 | CAS Indexing Verification |
| Chemical Formula / MW | C8H10O / 122.16 g/mol | C8H10O / 122.16 g/mol | MS / Stoichiometric Analysis |
| Appearance | Off-white to Pale Yellow Solid | Pure White Crystalline Flakes / Needles | Visual Inspection |
| Assay Purity (GC) | ≥ 98.5% | ≥ 99.5% (Isomeric Peak Pure) | Gas Chromatography (FID) |
| Melting Point Range | 63.0 °C – 67.0 °C | 66.0 °C – 68.5 °C | Capillary Melting Method |
| Boiling Point (760 mmHg) | 221.0 °C – 223.0 °C | 221.5 °C – 222.5 °C | Distillation Point ASTM D1078 |
| Moisture Content (Water) | ≤ 0.3% | ≤ 0.05% | Karl Fischer Coulometric Method |
| Free Phenol / Cresol Residual | ≤ 0.5% | ≤ 0.1% | HPLC / GC-MS Trace Analysis |
Achieving ultra-high isomeric purity is vital for downstream reactions. For example, during the synthesis of 4-chloro-3,5-dimethylphenol (Chloroxylenol / PCMX, CAS 88-04-0), the presence of isomeric 2,4-xylenol or 2,6-xylenol leads to unwanted chlorinated toxic by-products that lower the biocidal efficacy and compromise regulatory approvals in personal care products. Enterprise buyer diligence must ensure supplier validation of fractional crystallization and catalytic alkylation processes.
The global demand for 5-xylenol and derivative alkylphenols is experiencing a structural compound annual growth rate (CAGR) estimated at 5.8% through 2035. Driven by expanding applications in high-frequency 5G/6G copper-clad laminates (CCL), specialty polyphenylene ether (PPE/PPO) engineering plastics, agricultural crop protection, and healthcare disinfectants, the industrial demand has shifted dramatically towards strategic direct-factory contracts.
Post-pandemic hygiene protocols and institutional disinfectant usage have cemented 3,5-xylenol as the key precursor for PCMX and IPMP (4-Isopropyl-3-methylphenol). Global antiseptic manufacturers require multi-ton monthly delivery stability with guaranteed low trace metals.
Modified polyphenylene ether (PPE) synthesized from high-purity dimethylphenol isomers yields exceptionally low dielectric constants (Dk) and dissipation factors (Df). This is critical for next-gen artificial intelligence servers, printed circuit boards (PCB), and automotive radar modules.
Synthesizing selective herbicides, insecticides, and systemic fungicides relies on 3,5-xylenol derivatives. Global crop protection players in North America, South America, and Europe are transitioning to consolidated primary factory suppliers to insulate supply chains against spot market volatility.
At JIMPOCHEM, 5-xylenol is produced utilizing state-of-the-art vapor-phase catalytic methylation of phenol or selective isomerization of crude xylenol fractions. Our proprietary process design achieves maximum thermodynamic conversion with minimal energy consumption and zero direct emissions.
Phenol reacted with methanol over custom-engineered iron-magnesium oxide catalyst beds at optimized temperatures yields high selectivities for 3,5-xylenol. Multi-stage fractional distillation columns split light ortho-substituted cresols from the target dimethylphenol stream.
To reach pure white high-grade ≥99.5% specification, crude 5-xylenol undergoes melt crystallization or solvent-assisted recrystallization. This step completely strips out isomer traces (such as 2,5-xylenol and 2,3-xylenol), delivering flawless crystals suitable for sensitive pharmaceutical synthesis.
Every batch delivered from our Jinan manufacturing facility undergoes rigorous testing: Gas Chromatography (GC-FID/GC-MS) for isomer distribution, Karl Fischer titration for moisture, ICP-MS for heavy metals (≤1 ppm), and colorimetric Hazen scale evaluation (≤20 APHA).
JIMPOCHEM’s supply infrastructure goes beyond simple chemical delivery. We engineer targeted chemical solutions tailored to downstream manufacturing lines, optimizing total operational cost and batch-to-batch predictability.
Our low-color 5-xylenol serves as the direct feedstock for Chloroxylenol (PCMX CAS 88-04-0) and 4-Isopropyl-3-methylphenol (IPMP CAS 3228-02-2). Formulators gain enhanced antibacterial performance, superior formulation clarity, and compliance with EU ECHA Biocidal Products Regulation (BPR).
In electronic laminates, trace phenolic impurities lead to micro-voids and dielectric breakdown. JIMPOCHEM’s electronic-grade 5-xylenol ensures high glass transition temperatures (Tg > 180 °C), minimal thermal expansion, and optimal signal integrity for high-speed computation board substrates.
Providing custom purity profiles with low residual solvent mandates for pharmaceutical synthesis. Supported by comprehensive DMF documentation, ISO 9001 certified batch records, and full elemental impurity profiles according to ICH Q3D standards.
JIMPOCHEM CO., LTD was established in 2010 and is headquartered in the chemical industry hub of Jinan City, Shandong Province. Spanning a modern manufacturing footprints exceeding 500 acres, JIMPOCHEM is a professional chemical raw material manufacturer integrating advanced R&D, mass production, international trade, and technical service solutions.
Adhering to the core philosophy that "Quality Leads the Future," our management systems are certified under ISO 9001 (Quality Management), ISO 14001 (Environmental Management), and ISO 45001 (Occupational Health & Safety). Our expert technical team comprises industry veterans with over 10 to 16+ years of specialized experience in fine chemical synthesis and process engineering.
Leveraging strategic raw material procurement channels and partnerships with top global producers, we ensure continuous batch reliability. Our automated digital production plant balances large-scale continuous runs with agile custom synthesis, delivering rapid response times for high-volume enterprise contracts.
From raw material entry to final dispatch, every consignment is evaluated against strict technical specs. Our barcode-enabled batch traceability system allows customers to access raw material provenance, in-process analytical parameters, COA test results, and logistics milestones instantly.
In line with global decarbonization goals, JIMPOCHEM invests heavily in green chemical manufacturing. We utilize closed-loop catalytic oxidation for waste gas treatment, advanced wastewater recycling, and energy recovery systems, empowering our customers to achieve zero-carbon supply chains.
Navigating chemical international trade demands absolute regulatory alignment and hazard-compliant logistics. JIMPOCHEM provides seamless end-to-end support for procurement clients across Europe, the Americas, Asia-Pacific, and the Middle East.
Complete REACH compliance for the European Union, TSCA inventory status for North America, K-REACH verification for South Korea, and IECSC listing for China. Provided with multi-lingual GHS SDS (16 sections), COA, and Certificate of Origin (Form E, Form F, EUR.1).
Available in UN-approved 200L steel drums (200 kg net), 25 kg fiber drums with aluminum moisture barrier liners, or heated ISO Tanks (20–24 metric tons) for molten bulk supply. Compliant with IMDG (Sea), ICAO/IATA (Air), and ADR (Road) safety standards.
Strategic stock positions maintained near major shipping ports (Qingdao, Shanghai, Rotterdam, Houston) enable shortened lead times (JIT delivery options) and mitigate regional supply chain disruptions.
As the chemical market transitions towards circular economy models and ultra-low carbon intensity, JIMPOCHEM’s R&D division is driving innovation in two core technological domains:
Developing green synthesis routes utilizing bio-methanol and lignin-derived phenolic substrates to offer zero-fossil-carbon 3,5-xylenol options for eco-conscious consumer brands and sustainable polymer resins.
Scaling sub-ppm metal purification techniques to supply semiconductor-grade dimethylphenol monomers for EUV photoresist resins, advanced semiconductor packaging, and micro-optical materials.
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