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In the evolving global landscape of fine chemicals, biopharmaceuticals, and high-end cosmetic manufacturing, securing a dependable, ultra-pure supplier for Trometamol (CAS 77-86-1)—frequently referred to as Tris Base, Tromethamine, or 2-Amino-2-hydroxymethyl-propane-1,3-diol—is a critical strategic priority for procurement directors and product formulation engineers alike.
Trometamol acts as a robust primary biological buffer and versatile synthetic building block. With an effective buffering range between pH 7.0 and 9.0 (pKa = 8.06 at 25°C), it serves as an indispensable stabilizing agent across cell culture media, molecular diagnostic assays, mRNA vaccine formulations, topical dermo-cosmetic preparations, and specialty industrial polymer processing. This dossier delivers an authoritative evaluation of global supply dynamics, rigorous quality parameters, advanced manufacturing methodologies, and procurement risk-mitigation frameworks.
Understanding the exact chemical profile and purity thresholds of Trometamol is essential for maintaining strict compliance with global pharmacopeial standards (USP, EP, JP, ChP). Below is the comprehensive analytical baseline maintained by top-tier producers like JIMPOCHEM:
| Parameter Parameter | Standard Specification (Pharmaceutical Grade) | Industrial / Tech Grade Specification | Analytical Test Method |
|---|---|---|---|
| Chemical Name | 2-Amino-2-hydroxymethyl-propane-1,3-diol | Tromethamine / Tris Base | IUPAC Nomenclature |
| CAS Registry Number | 77-86-1 | 77-86-1 | CAS Index |
| Molecular Formula / Weight | C4H11NO3 / 121.14 g/mol | C4H11NO3 / 121.14 g/mol | Mass Spectrometry |
| Assay (Purity on Dry Basis) | 99.5% – 100.5% | ≥ 99.0% | Acid-Base Titration / HPLC |
| Melting Point Range | 168.0 °C to 172.0 °C | 166.0 °C to 172.0 °C | Capillary Melting Method |
| Bacterial Endotoxins | < 0.03 EU/mg (Injectable Grade) | Not Specified | LAL Kinetic Chromogenic Test |
| Heavy Metals (as Pb) | ≤ 1 ppm (Ultra-Pure) | ≤ 10 ppm | ICP-MS / Atomic Absorption |
| UV Absorbance (260 nm / 280 nm) | ≤ 0.02 / ≤ 0.01 (40% Aq. Solution) | ≤ 0.10 | UV-Vis Spectrophotometry |
From Life Sciences to High-Performance Synthetic Materials: How Trometamol Drives Global Manufacturing Innovations.
Essential buffer in mRNA vaccine delivery (LNP systems), monoclonal antibody purification, enzyme stabilization, and injectable physiological formulation under stringent low-endotoxin requirements.
Core element in TAE/TBE electrophoresis buffers, real-time PCR reaction mixtures, lysis buffers for nucleic acid extraction, and automated clinical chemistry analyzer reagents.
Premium mild neutralizing agent replacing harsh alkanolamines (TEA/DEA). Provides optimal pH adjustments in sensitive skin creams, anti-aging serums, and eye care gels without skin irritation.
Acts as a multi-functional synthons in preparing specialty surfactants, water treatment scale inhibitors, vulcanization accelerators, and synthetic resin crosslinkers.
Used as an active pharmaceutical ingredient (API) in osmotic diuretic treatments and acute metabolic acidosis correction agents, acting as an amine proton acceptor in blood plasma.
Functions as a pigment dispersant and corrosion inhibitor in waterborne industrial coatings, improving film clarity, adhesion stability, and moisture resistance.
How JIMPOCHEM leverages 500+ acres of integrated chemical production capacity in Jinan Chemical Park to deliver unmatched cost efficiency, scale, and compliance.
Global procurement executives face continuous market volatility, energy price fluctuations, and strict regulatory overhauls. Chinese manufacturing clusters—specifically JIMPOCHEM's state-of-the-art facility in Jinan, Shandong Province—provide structural supply advantages through vertical raw material integration, continuous-flow automated processing, and green synthesis technologies.
Direct access to upstream formaldehyde and nitromethane feedstocks ensures stable continuous production without raw material bottlenecks, guaranteeing 100% order fulfillment even during regional supply squeezes.
Our modern production facility utilizes digital DCS intelligent control systems for automated multi-stage recrystallization, ensuring ultra-pure crystal particle size distribution with minimal endotoxin accumulation.
Equipped with high-efficiency MVR wastewater evaporation systems and zero-VOC catalytic gas scrubbers, helping downstream buyers achieve green supply chain transformation and ESG compliance.
Established in 2010 | Designated Chemical Service Provider | ISO 9001 & ISO 14001 Certified
JIMPOCHEM CO., LTD was established in 2010 and is headquartered in the Chemical Industry Park of Jinan City, Shandong Province. Spanning an area of over 500 acres, the company is a professional chemical raw material manufacturer integrating advanced research and development, continuous large-scale production, global sales, and specialized technical support.
Our core operational focus covers high-end fine chemicals, biopharmaceutical buffers, and cosmetic active raw materials. Adhering to the core philosophy that "Quality Leads the Future," our technical team comprises industry veterans with over 10 years of chemical engineering expertise. This allows us to provide custom solution engineering, formulation optimization, and seamless supply chain integration to meet personalized global procurement requirements.
Today, our high-purity product lines are exported to more than 200 countries and regions across Europe, the Americas, Southeast Asia, the Middle East, and Oceania, serving over 5,000 international corporate clients and maintaining long-term strategic partnerships with leading global chemical conglomerates.
Take a visual tour of our corporate exterior, advanced synthesis equipment, R&D analytical laboratories, and secure packaging operations.
When sourcing bulk Trometamol for sensitive application scenarios—such as biopharmaceutical buffer compounding, parenteral drug manufacturing, or high-end cosmetic formulations—procurement heads must perform rigorous supplier audits to guarantee regulatory compliance and lot-to-lot purity uniformity.
A reliable supplier must provide a complete technical documentation package for every batch, including:
Trometamol is moderately hygroscopic and sensitive to ambient carbon dioxide absorption (forming amine carbonates over extended periods). Proper moisture-barrier packaging is critical:
The global demand for Trometamol is projected to grow at a CAGR of 6.8% over the next decade, propelled by rapid expansion in cell and gene therapy (CGT) platforms, global mRNA vaccine manufacturing pipelines, and green cosmetics formulation shifts. Partnering with a vertically integrated manufacturer like JIMPOCHEM guarantees price predictability and long-term contract stability.
Answers to critical technical, sourcing, and logistics queries for industrial and pharmaceutical chemical buyers.
There is no chemical difference. Trometamol (recommended INN name), Tris Base (common laboratory name), and Tromethamine (USP monograph title) all refer to the identical chemical compound: 2-Amino-2-hydroxymethyl-propane-1,3-diol (CAS 77-86-1). It should not be confused with Tris HCl (Tris Hydrochloride, CAS 1185-53-1), which is the pre-neutralized salt form.
JIMPOCHEM manufactures three distinct grades tailored to industry needs: (1) Pharmaceutical / Injectable Grade (Assay ≥ 99.5%, Endotoxin < 0.03 EU/mg, low heavy metals), (2) Diagnostic / Molecular Biology Grade (DNase/RNase-free, ultra-low UV absorbance), and (3) Cosmetic & Industrial Grade (Assay ≥ 99.0% for pH regulation and chemical synthesis).
Trometamol is a primary amine with significantly lower sensitization and irritation profiles compared to secondary or tertiary alkanolamines like TEA or DEA. Additionally, Trometamol does not carry the risk of nitrosamine contamination, making it compliant with strict global clean-beauty regulations (such as EU Regulation EC 1223/2009).
Our standard MOQ for commercial orders is 25 kg (1 full fiber drum). For evaluation and R&D laboratory qualification, we provide free 100g to 500g sample packs upon request with fast international courier dispatch (DHL/FedEx).
Our injectable grade production line operates under ISO 7 (Class 10,000) cleanroom conditions, utilizing purified water systems (WFI standard) and specialized ultrafiltration carbon crystallization processes to ensure consistent endotoxin levels well below USP/EP limits.
Store in tightly closed original containers in a cool, dry, well-ventilated warehouse space (recommended 15°C to 25°C). Keep protected from moisture and direct sunlight. Under these conditions, the product maintains a stable shelf life of 36 months from manufacturing.
Complete supply chain coverage for daily chemicals, active ingredients, and industrial synthons.
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