Direct Factory Supply with Global Regulatory Compliance & Batch Traceability
An In-Depth Engineering Review of 4-Isopropyl-3-methylphenol (CAS 3228-02-2 / 39660-61-2)
EMA 3228 (chemically identified as 4-isopropyl-3-methylphenol, commercially designated under INCI as o-Cymen-5-ol and registered under CAS numbers 3228-02-2 and 39660-61-2) represents a apex-tier phenolic antimicrobial agent. Known for its exceptional structural stability, low toxicity index, and broad-spectrum bactericidal and fungicidal properties, EMA 3228 has established itself as an indispensable active raw material across high-end cosmetic formulations, pharmaceutical dermatological topicals, semiconductor cleanroom disinfectants, and advanced polymer preservative systems.
From a molecular design perspective, the presence of the isopropyl group at the C4 position paired with the methyl substitution at C3 confers heightened lipophilicity compared to classic simple phenols or chlorinated biocides like PCMX (Chloroxylenol) and Triclosan. This enhanced lipophilic profile allows EMA 3228 to rapidly permeate bacterial cell membranes and fungal cell walls, disrupting transmembrane electrochemical gradients, deactivating crucial intracellular metabolic enzymes, and causing irreversible denaturation of microbial proteins without exerting severe cytotoxicity on human epidermal skin structures.
Information Gain Key Takeaway: Unlike traditional halogenated preservatives subject to strict environmental restrictions (e.g., bioaccumulation of chlorinated aromatics), EMA 3228 offers a non-halogenated, highly biodegradable profile while maintaining superior Minimum Inhibitory Concentrations (MIC) against resistant strains such as Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans.
| Specification Parameter | Technical Standard / Guarantee | Analytical Method |
|---|---|---|
| Chemical Name | 4-Isopropyl-3-methylphenol / o-Cymen-5-ol | IUPAC Nomenclature |
| CAS Registry Number | 3228-02-2 / 39660-61-2 | CAS Database |
| Assay / Purity (Dry Basis) | ≥ 99.5% (Typical 99.8%) | HPLC (High-Performance Liquid Chromatography) |
| Appearance | White to Off-White Crystalline Powder / Needles | Visual Inspection |
| Melting Point Range | 110.0 °C – 113.0 °C | Capillary Melting Point Apparatus |
| Boiling Point | 244.8 °C at 760 mmHg | Distillation Standard |
| Solubility Profile | Freely soluble in Ethanol, Acetone, Isopropanol; Soluble in oils; Slightly soluble in water (approx. 0.27 g/L at 20°C) | Gravimetric Dissolution Method |
| Heavy Metals (as Pb) | ≤ 10 ppm | ICP-MS Spectrometry |
| Residue on Ignition / Ash | ≤ 0.05% | Muffle Furnace Thermo-gravimetry |
Delivering Targeted Antimicrobial Efficacy Across High-Value Global Industries
Used widely in anti-acne serums, scalp protection shampoos, body washes, and oral hygiene formulations. EMA 3228 acts as a non-irritating preservative stabilizer that inhibits Propionibacterium acnes and Malassezia furfur at minimal active concentrations (0.05% - 0.1%).
Integrated into OTC dermatological creams, antiseptic ointments, and surgical skin preparation gels. It exhibits excellent synergy when combined with secondary active ingredients like Salicylic Acid or Zinc Pyrithione to prevent secondary microbial skin infections.
Acts as an in-can preservative and dry-film bio-shield in high-end architectural coatings, silicone sealants, and industrial plastics. Maintains thermal stability up to 200°C during high-temperature polymer extrusion processing.
Formulated into specialty optical surface cleaners and semiconductor cleanroom surface disinfectants. EMA 3228 leaves negligible ionic residue, preventing micro-corrosion on delicate aluminum and copper circuits.
Prevents bio-degradation and fungal dry-rot in industrial sealing gaskets, automotive rubber hoses, and tire compounds exposed to humid, tropical operational environments.
Key active component in hard-surface hospital-grade disinfectants, deodorizing sprays, and high-efficiency commercial laundry sanitizers requiring long-lasting residual antimicrobial action.
Pioneering Fine Chemical Manufacturing Excellence and Global Logistics Integration
JIMPOCHEM CO., LTD was established in 2010 and is headquartered in the Chemical Industry Park of Jinan City, Shandong Province. The company covers an area of over 500 acres and is a professional chemical raw material manufacturer that integrates research and development, production, sales, and technical services. Its core focus is on high-end fine chemicals and cosmetic raw materials. We have obtained multiple product-related certifications, including ISO quality system certification and environmental management system certification, and are committed to providing high-quality chemical products and one-stop procurement service solutions to global customers.
Our core team comprises experts with over 16 years of experience in the chemical industry. This enables us not only to provide professional products but also to offer solutions in product development, formula optimization, and supply chain management, meeting the personalized needs of diverse clients. We provide high-quality products and services, and our products are exported to over 200 countries and regions in Europe, America, Southeast Asia, the Middle East, and Oceania, serving more than 5,000 international companies. We have also established long-term strategic partnerships with many internationally renowned chemical companies, becoming a trusted designated chemical service provider for numerous clients.
Leveraging years of industry experience, we have established stable raw material procurement channels and partnered with top global chemical raw material suppliers, ensuring stable raw material quality and ample supply. Our modern production base employs an intelligent control system to automate and digitally manage the production process, balancing large-scale production with flexible customization needs. This allows for rapid response to large-volume orders and personalized product requests from our clients.
Adhering to the philosophy that "quality is the lifeline of an enterprise," the company has established a comprehensive quality control system. From raw material warehousing and inspection, real-time monitoring of the production process, to full-item inspection of finished products before shipment, every step adheres to strict quality standards to ensure that every batch of products delivered to customers meets relevant technical specifications. Simultaneously, a product traceability system has been established, allowing users to trace raw materials, production process, testing data, and logistics through batch numbers.
In response to the global "dual-carbon" strategy, the company focuses on the research and development and production of green chemical products, adopting environmentally friendly production processes and optimizing wastewater, waste gas, and waste residue treatment systems to achieve compliant pollutant emissions and resource recycling. Many core products have obtained environmental certifications, helping downstream customers achieve green production transformation.
Forecasting Innovation in Eco-Friendly Antimicrobial Synthesis & Smart Formulations
Transitioning from classic alkylation reaction routes toward solid acid heterogeneous catalysis. This eliminates acid waste streams, lowers carbon footprint by 35%, and yields an ultra-pure crystal grade of EMA 3228 exceeding 99.9% HPLC purity for sensitive biomedical applications.
Development of lipid nanoparticles (LNPs) and cyclodextrin complexation technologies for EMA 3228. Controlled-release systems will prolong antimicrobial efficacy in aquatic and atmospheric coating environments while reducing water solubility wash-out rates by 60%.
Integrating high-throughput machine learning algorithms to predict synergy ratios between EMA 3228 and natural botanical preservatives (e.g., Thymol, Carvacrol). This achieves hyper-effective anti-spoilage performance while minimizing total active dosage thresholds.
Fully Certified for International Market Access Across EU, US, and APAC Jurisdictions
Navigating global regulatory landscapes requires meticulous chemical safety documentation and strict quality parameters. EMA 3228 (o-Cymen-5-ol) manufactured by JIMPOCHEM complies fully with major global regulatory frameworks:
Technical Support Guarantee: JIMPOCHEM provides full technical support dossiers, including SDS (Safety Data Sheets compliant with GHS Revision 9), Certificate of Analysis (CoA) per lot, Heavy Metal Analysis, Allergen Statements, and BSE/TSE-Free Declarations for every client order.
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