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Established in 2010 and strategically headquartered in the Chemical Industry Park of Jinan City, Shandong Province, JIMPOCHEM CO., LTD operates an advanced manufacturing and R&D footprint covering over 500 acres. As a premier chemical raw material manufacturer, we seamlessly integrate research, industrial synthesis, global sales, and technical consultation to serve high-end fine chemicals, pharmaceutical APIs, and specialized cosmetic industries worldwide.
Holding comprehensive international certifications—including ISO 9001 Quality Management Systems and ISO 14001 Environmental Management Standards—JIMPOCHEM is dedicated to delivering high-purity chemical compounds alongside end-to-end procurement solutions for multinational enterprises.
Our executive core team comprises senior industrial chemists and supply chain engineers with over a decade of hands-on experience. We empower over 5,000 international companies across Europe, North America, Southeast Asia, the Middle East, and Oceania with tailored formulations, reliable scaling, and continuous supply stability.
Molecular specifications, chemical structure analysis, and analytical standard requirements for high-purity procurement.
CAS Number 70-18-8 corresponds to L-Glutathione Reduced (GSH), a crucial tripeptide chemically defined as γ-L-Glutamyl-L-cysteinyl-glycine (Molecular Formula: C10H17N3O6S; Molecular Weight: 307.32 g/mol). Characterized by an active sulfhydryl (-SH) functional group situated on the cysteine residue, CAS 70-18-8 serves as the master biological antioxidant and cellular nucleophile in biochemical pathways.
Unlike standard amino acid mixtures, the unique gamma-peptide linkage between the glutamate side-chain carboxyl group and the amine of cysteine protects CAS 70-18-8 from cleavage by conventional cellular peptidases. In industrial applications, maintaining the sulfur atom in its reduced state (GSH) rather than its oxidized dimeric state (GSSG, CAS 27025-41-8) requires strictly controlled crystallization, specialized anti-oxidative packaging, and strict control of redox potentials during production.
| Analytical Parameter | USP / EP Grade Standard Specification | JIMPOCHEM Enterprise Benchmark |
|---|---|---|
| Appearance | White crystalline powder | White crystalline powder (Free-flowing) |
| Chemical Assay (HPLC) | 98.0% - 101.0% (Dried basis) | ≥ 99.5% Ultra-Pure |
| Identification (FTIR / HPLC) | Conforms to reference standard | Conforms 100% to USP/EP Reference |
| Specific Optical Rotation [α]D20 | -15.5° to -17.5° | -16.0° to -17.0° |
| Heavy Metals (as Pb) | ≤ 10 ppm | ≤ 5 ppm |
| Arsenic (As) | ≤ 1 ppm | ≤ 0.5 ppm |
| Loss on Drying | ≤ 0.5% | ≤ 0.3% |
| Residue on Ignition (Sulfated Ash) | ≤ 0.1% | ≤ 0.05% |
| Related Substances (GSSG) | ≤ 1.5% | ≤ 0.5% |
How enterprise buyers integrate CAS 70-18-8 across pharmaceutical formulation, cosmeceuticals, advanced bio-nutraceuticals, and food engineering.
CAS 70-18-8 serves as an essential Active Pharmaceutical Ingredient (API) and intermediate. Utilized in hepatoprotective injections, systemic antidote therapies for heavy metal poisoning, chemotherapy protective agents, and advanced ophthalmic formulations for cataract prevention. Enterprise pharmaceutical buyers demand strict cGMP compliance and low endotoxin thresholds.
In high-end skincare, reduced glutathione suppresses melanin synthesis by directly inhibiting tyrosinase enzymes and switching melanin synthesis from dark eumelanin to light pheomelanin. Formulators incorporate high-purity CAS 70-18-8 into brightening serums, sublingual tablets, and anti-photoaging creams to yield systemic hyperpigmentation reduction.
Addressing historical bioavailability hurdles, modern nutraceutical brands utilize CAS 70-18-8 in liposomal entrapment systems, enteric-coated capsules, and S-acetyl-glutathione precursors. High bulk density and uniform particle size distributions ensure seamless capsule filling and stable suspension in lipid matrices without premature oxidation.
Used extensively in enology (winemaking) to preserve delicate aromatic thiols and prevent non-enzymatic browning. In commercial baking, CAS 70-18-8 acts as a natural dough relaxer by cleaving gluten disulfide bonds, facilitating dough handling, expanding volume, and standardizing industrial baking cycles.
Essential component in serum-free cell culture media for mammalian cell line propagation (CHO cells, HEK293). It protects recombinant protein expression from oxidative stress, neutralizes accumulated reactive oxygen species (ROS), and stabilizes biopharmaceutical yield during bioreactor scale-up.
Integrated into premium aquaculture feeds to bolster hepatopancreas immunity in shrimp and teleost fish. Glutathione supplementation lowers mortality caused by intensive farming stressors, pathogen challenges, and environmental temperature fluctuations.
Navigating international supply chains, bulk pricing structures, packaging standards, and cold-chain integrity.
The global market for Reduced L-Glutathione (CAS 70-18-8) continues an upward trajectory, driven by compound annual growth rates (CAGR) exceeding 7.8% across North America, Europe, and Asia-Pacific. Key drivers include expanding cosmeceutical demands in East Asia, increased oral liposomal product launches in the US, and growing parenteral drug manufacturing in Europe.
As a tier-one chemical direct manufacturer from Jinan, Shandong, JIMPOCHEM bridges critical supply chain gaps by maintaining large-scale precursor buffers (L-Cysteine, L-Glutamic Acid, Glycine), insulating global B2B clients from regional raw material price volatility.
The primary technical risk during international transit of CAS 70-18-8 is atmospheric oxidation into oxidized glutathione (GSSG). JIMPOCHEM enforces multi-layer protective packaging protocols:
Advancing from traditional yeast extraction to high-density enzymatic fermentation and sustainable green bio-manufacturing.
Historically, reduced glutathione was extracted from natural yeast cultures (such as Saccharomyces cerevisiae or Candida utilis). However, extraction yields remained low (<2.5% dry cell weight), resulting in high costs and substantial waste streams. JIMPOCHEM’s technical roadmap highlights a transition toward state-of-the-art biological pathways:
Genetically optimized yeast strains coupled with computer-controlled glucose fed-batch feeding, boosting intracellular GSH accumulation past 12.5% dry cell mass.
Coupling Glutamylcysteine Synthetase (GCS) and Glutathione Synthetase (GS) with continuous ATP regeneration systems, reaching quantitative conversions with zero toxic chemical byproducts.
Membrane filtration, nano-filtration, and anti-solvent crystallization techniques eliminate heavy chemical reagents, drastically lowering E-factor metrics and energy consumption.
Ensuring complete regulatory documentation, audit readiness, and global market access for life science partners.
We provide complete technical dossiers for worldwide registration: Certificate of Analysis (CoA) per batch, Safety Data Sheets (SDS/MSDS) compliant with GHS, DMF (Drug Master File), TSE/BSE-Free Statements, Non-GMO verification, and Allergen Statements.
Every batch undergoes full analytical testing via High-Performance Liquid Chromatography (HPLC), Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for heavy metals, and automated microbial limit testing before quality release.
Our facility holds accredited ISO 9001, ISO 14001, cGMP, HALAL, and KOSHER certifications, meeting all food, cosmetics, and pharmaceutical regulatory frameworks in North America, the European Union, Asia, and Latin America.
Discover JIMPOCHEM's extended catalog covering Daily Chemicals, Organic Intermediates, Health Care APIs, and Fluorine Compounds.
Cosmetics, makeup, perfume, facial cleansers, hand sanitizers, body wash, toothpaste, specialized surfactants, and anti-photoaging active ingredients.
Production of active pharmaceutical ingredients (API), pharmaceutical excipients, organic intermediates, high-purity reaction solvents, catalysts, and medical anesthesia raw materials.
Packaging polymers, automobile seals, tire manufacturing additives, architectural and decorative coatings, printing inks, and specialty industrial resin modifiers.
Preservatives, natural antioxidant colorants, nutritional fortifiers, dough conditioners, and aquaculture immune enhancers.
Semiconductor micro-cleaning solvents, printed circuit board (PCB) etching chemicals, display panel materials, lithium battery electrolytes (LITFSI), and fluorinated specialty compounds.
One-on-one technical services for customized batch synthesis, formulation optimization, structural elucidation, and process scaling up to multi-ton commercial production.
Select from our certified range of global industrial supply solutions.
Expert technical and commercial guidance for purchasing Reduced L-Glutathione bulk raw material.
JIMPOCHEM manufactures Reduced L-Glutathione (CAS 70-18-8) to exceed strict USP, EP, and JP monograph standards. Our standard commercial batches consistently test at ≥ 99.5% HPLC purity with total oxidized glutathione (GSSG) controlled strictly under 0.5%.
Reduced L-Glutathione is sensitive to moisture and oxidation. We package CAS 70-18-8 in double PE inner pharma-grade bags, vacuum-sealed inside heavy-duty aluminum foil bags flushed with inert Nitrogen gas (N2), and packed in 25kg fiber drums. Temperature-controlled reefer containers are deployed for warm climates upon customer request.
Every bulk order includes a batch-specific Certificate of Analysis (CoA), GHS-compliant Safety Data Sheet (SDS/MSDS), ISO 9001/14001 certificates, Non-GMO statement, TSE/BSE-free certification, and Allergen-free declaration. Full cGMP audit support and DMF documentation are available for pharmaceutical buyers.
We supply evaluation samples starting at 100g to 1kg for R&D laboratories (shipped via express courier within 24-48 hours). Commercial MOQ starts at 25kg (1 standard drum). Large scale contract procurement (metric ton scale) is dispatched within 7–14 business days from our Jinan manufacturing hub.
Yes. We offer customized physical processing, including customized micronization for fine powder cosmetics, high-bulk-density milling for hard gelatin capsule filling, and specialized granulations optimized for direct compression tablets.
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