High-purity fine chemical ingredients directly sourced from certified China smart manufacturing units.
Comprehensive physical-chemical parameters, structural identification, and purity specifications for enterprise procurement.
CAS 3228-02-2 (also frequently cross-referenced under CAS 39660-61-2 and chemically identified as 4-Isopropyl-3-methylphenol or o-Cymen-5-ol) represents an extraordinary isomeric phenolic compound recognized globally for its superior broad-spectrum antimicrobial, antifungal, and antioxidant activity. Widely utilized in cosmetic preservation, anti-acne dermatological formulations, oral healthcare, and specialized industrial biocides, IPMP provides superior stability and low mucosal irritation compared to conventional halogenated or formaldehyde-releasing preservatives.
| Parameter | Technical Specification / Standard | Analytical Method |
|---|---|---|
| Chemical Name | 4-Isopropyl-3-methylphenol; o-Cymen-5-ol; 3-Methyl-4-isopropylphenol | IUPAC Nomenclature |
| CAS Registry Number | 3228-02-2 / 39660-61-2 | CAS Database Verification |
| Molecular Formula / Weight | C10H14O / 150.22 g/mol | Mass Spectrometry (MS) |
| Assay Purity (GC) | ≥ 99.5% (High Purity Grade available at ≥ 99.9%) | Gas Chromatography (FID) |
| Appearance | White to off-white crystalline solid / needle-like crystals | Visual Inspection |
| Melting Point | 110.0 °C to 113.0 °C | Capillary Melting Apparatus |
| Solubility Profile | Practically insoluble in water (~0.27 g/L at 20°C); Freely soluble in Ethanol, Isopropanol, Acetone, and cosmetic oils | Gravimetric Analysis |
| Heavy Metals (as Pb) | ≤ 10 ppm max | ICP-MS |
| Residue on Ignition | ≤ 0.10% max | Thermogravimetric Furnace |
Unlike traditional preservatives that rely on irreversible cellular alkylation or heavy metal ion deposition, 4-Isopropyl-3-methylphenol operates via physical disruption of the microbial lipid bilayer. Its lipophilic isopropyl ring facilitates rapid insertion into bacterial plasma membranes, causing intracellular potassium and ATP leakage while neutralizing membrane potential. This physical mode of action renders resistance development virtually impossible among targeted microflora including Cutibacterium acnes and Malassezia furfur.
Advancing green chemical pathways and continuous flow synthesis for ultra-pure CAS 3228-02-2 production.
Conventional synthetic routes often suffer from non-selective alkylation of meta-cresol with propylene or isopropanol, generating unwanted 2-isopropyl isomers. JIMPOCHEM utilizes proprietary modified zeolite solid-acid catalysts (H-beta/ZSM-5 micro-porous matrices) that achieve >98.2% para/ortho regioselectivity, dramatically minimizing byproduct yield and simplifying downstream purification crystallization.
To eliminate batch-to-batch thermal gradients and localized hot spots, our production units transition to continuous micro-fluidic flow reactors. Precise residence time control and intense micro-mixing enable near-instantaneous heat exchange, narrowing impurity profiles and guaranteeing consistent HPLC assay purity exceeding 99.5% continuously.
Aligning with 2030 global carbon-neutral mandates, chemical research at JIMPOCHEM focuses on catalytic conversion of bio-derived terpene feedstocks (such as thymol and p-cymene derivatives) into CAS 3228-02-2 via isomerisation. Closed-loop solvent extraction combined with green crystallization reduces carbon intensity by 42% per ton produced.
Versatile active applications across cosmetic formulations, oral therapeutics, medical disinfectants, and industrial polymer preservation.
Acts as an anti-acne active and broad-spectrum preservative in creams, serums, and cleansers. Effective at minimal dosage (0.05% - 0.1%), neutralizing acne-causing bacteria without destabilizing lipid emulsions.
Widely integrated into therapeutic mouthwashes, anti-gingivitis toothpastes, and oral sprays. Provides long-lasting anti-plaque performance through suppression of Streptococcus mutans biofilm growth.
Utilized as an active antimicrobial agent in topical antiseptics, surgical skin cleansers, and wound dressing sprays due to its non-corrosive, non-sensitizing skin contact toxicity profile.
Serves as a robust bio-stabilizer and antifungal agent in high-end coatings, synthetic rubber gaskets, optical materials, and precision electronic packaging vulnerable to fungal degradation.
Full regulatory dossier support ensuring seamless clearance and compliance in EU, US, and Asian markets.
O-Cymen-5-ol (CAS 3228-02-2) is listed under Annex V (Entry 38) as an allowed preservative in cosmetic products up to a maximum concentration of 0.1%. Fully compliant with EU SCCS safety evaluations.
Registered under EU REACH, US TSCA, China IECSC, Japan ENCS, and Korean ECL. Ready for large-scale enterprise importation with complete REACH tonnage bandwidth.
Every shipment is accompanied by batch-specific Certificate of Analysis (COA), SDS/MSDS (GHS compliant), Technical Data Sheet (TDS), Allergen Statements, BSE/TSE-Free Certificates, and Non-GMO verification.
Integrated manufacturing hub in Jinan Chemical Industry Park delivering total reliability.
JIMPOCHEM CO., LTD leverages digitalized DCS central control rooms, automated raw material charge systems, and zero-discharge environmental safety frameworks. Our redundant production lines guarantee uninterrupted raw material supply even during market volatility, offering global buyers cost stability and reliable delivery schedules.
Tailored packaging configurations designed to preserve high-purity crystalline integrity during sea and air transit.
25 kg net weight cardboard fiber drums lined with double-layer PE anti-static vacuum-sealed inner bags. Moisture-proof and light-shielded for extended shelf stability (36 months).
Flexible procurement quantities starting from 1 kg, 5 kg, and 10 kg aluminum foil barrier bags. Ideal for formulators, university R&D laboratories, and cosmetic pilot testing.
Seamless shipping execution via Qingdao, Shanghai, and Tianjin ports. Full dangerous/non-dangerous goods export handling, multimodal transport tracking, and customs clearance assistance.
Designated Chemical Service Provider | Leading Fine Chemical & Cosmetic Raw Material Manufacturer
JIMPOCHEM CO., LTD was established in 2010 and is headquartered in the Chemical Industry Park of Jinan City, Shandong Province. The company covers an area of over 500 acres and is a professional chemical raw material manufacturer that integrates research and development, production, sales, and technical services. Its core focus is on high-end fine chemicals and cosmetic raw materials. We have obtained multiple product-related certifications, including ISO quality system certification and environmental management system certification, and are committed to providing high-quality chemical products and one-stop procurement service solutions to global customers.
Our core team comprises experts with over 10 years of experience in the chemical industry. This enables us not only to provide professional products but also to offer solutions in product development, formula optimization, and supply chain management, meeting the personalized needs of diverse clients. We provide high-quality products and services, and our products are exported to over 200 countries and regions in Europe, America, Southeast Asia, the Middle East, and Oceania, serving more than 5,000 international companies.
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