China Zinc Omadine Manufacturers & Supplier

High-Purity Zinc Pyrithione (CAS 13463-41-7) | Technical Whitepaper & Global Industrial Supply Guide

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Comprehensive Technical Overview: Zinc Omadine (Zinc Pyrithione / ZPT)

Understanding the chemical architecture, antimicrobial mechanisms, and industrial purity benchmarks driving global demand.

Executive Summary for Procurement Officers & Formulators: Zinc Omadine, technically known as Zinc Pyrithione (ZPT, CAS 13463-41-7), is a coordination complex of zinc with pyrithione ligands. Recognized globally for its exceptionally broad-spectrum antifungal and antibacterial potency, ZPT serves as a critical active pharmaceutical ingredient (API), cosmetic anti-dandruff agent, and heavy-duty industrial biocide. Leading Chinese manufacturers now leverage advanced micro-dispersion and continuous-crystallization processes to deliver low-viscosity, high-stability grades optimized for international regulatory standards.

1. Chemical Properties & Structural Dynamics

Zinc Pyrithione exists as a coordination complex where two pyrithione ligands (2-pyridinethiol 1-oxide) coordinate to a central zinc ion ($C_{10}H_8N_2O_2S_2Zn$). The unique structural integrity of the complex imparts low aqueous solubility (~6-8 ppm at neutral pH), which is fundamental to its prolonged residue action and slow-release profile in coatings, personal care wash-offs, and polymer matrices.

Parameter Technical Specification (Powder Grade) Technical Specification (48% Aqueous Emulsion)
Chemical Name Bis(1-hydroxy-2(1H)-pyridinethionato-O,S)zinc Zinc Pyrithione Aqueous Dispersion
CAS Number 13463-41-7 13463-41-7
Active Content (Assay) ≥ 98.0% Min 48.0% - 50.0%
Particle Size ($D_{50}$) 1.2 µm – 1.8 µm (Micro-milled) 1.3 µm – 1.6 µm (Colloidal grade)
pH Value (1% water solution) 6.5 – 8.5 6.5 – 9.0
Heavy Metal Limits (Pb, As) Pb ≤ 10 ppm, As ≤ 2 ppm Pb ≤ 5 ppm, As ≤ 1 ppm

2. Antimicrobial Mechanism of Action

Unlike simple membrane disruptors, Zinc Omadine functions through a multi-targeted cellular disruption pathway. The primary bactericidal and fungicidal activity stems from its capacity to act as a copper ionophore and membrane potential collapser:

  • Proton Motive Force Collapse: ZPT translocates metal ions across cellular lipid bilayers, discharging the transmembrane proton gradient and abolishing ATP synthesis in fungi such as Malassezia globosa and Candida albicans.
  • Intracellular Copper Accumulation: ZPT increases intracellular copper levels within target microbes. The elevated free copper ions target and destroy iron-sulfur cluster proteins essential for fungal cellular respiration.
  • Transporter Inactivation: By binding to critical thiol groups on cell membrane transport proteins, ZPT prevents nutrient uptake and leads to metabolic stasis.

About JIMPOCHEM: Manufacturing Heritage & Global Supply Capabilities

Designated chemical service provider delivering quality, sustainability, and robust supply chain solutions globally.

JIMPOCHEM CO., LTD was established in 2010 and is headquartered in the Chemical Industry Park of Jinan City, Shandong Province. The company covers an area of over 500 acres and is a professional chemical raw material manufacturer that integrates research and development, production, sales, and technical services. Its core focus is on high-end fine chemicals and cosmetic raw materials. We have obtained multiple product-related certifications, including ISO quality system certification and environmental management system certification, and are committed to providing high-quality chemical products and one-stop procurement service solutions to global customers.

16+
Years of Industry Experience (Est. 2010)
500+
Acres Modern Production Campus
200+
Countries & Regions Exported To
5000+
International Enterprise Clients

Supply Chain & Production

Leveraging years of industry experience, we have established stable raw material procurement channels and partnered with top global chemical raw material suppliers, ensuring stable raw material quality and ample supply. Our modern production base employs an intelligent control system to automate and digitally manage the production process, balancing large-scale production with flexible customization needs. This allows for rapid response to large-volume orders and personalized product requests from our clients.

Rigorous Quality Control

Adhering to the philosophy that "quality is the lifeline of an enterprise," the company has established a comprehensive quality control system. From raw material warehousing and inspection, real-time monitoring of the production process, to full-item inspection of finished products before shipment, every step adheres to strict quality standards to ensure that every batch of products delivered to customers meets relevant technical specifications. Full batch traceability allows users to audit raw materials, testing data, and logistics through batch numbers.

Green & Environmental Commitment

In response to the global "dual-carbon" strategy, the company focuses on the research and development and production of green chemical products, adopting environmentally friendly production processes and optimizing wastewater, waste gas, and waste residue treatment systems to achieve compliant pollutant emissions and resource recycling. Many core products have obtained environmental certifications, helping downstream customers achieve green production transformation.

Localized Application Scenarios & Formulation Guide

Engineered solutions for personal care formulations, architectural coatings, marine paints, and polymer preservation.

Personal Care & Hair Formulation

Zinc Omadine (ZPT 48% Dispersion) is the gold-standard anti-dandruff agent globally. It inhibits the proliferation of Malassezia species responsible for scalp flaking and seborrheic dermatitis.

  • Shampoo Formulations: Recommended dosage ranges from 1.0% to 2.0% active concentration in rinse-off anti-dandruff treatments.
  • Suspension Chemistry: Requires acrylic or xanthan gum thickeners (e.g., Carbomer) paired with suitable density-matching agents to ensure long-term shelf stability without sediment compaction.

Industrial Coatings & Marine Paints

In exterior architectural latex paints and marine hull anti-fouling systems, ZPT acts as a heavy-duty algaecide and fungicide preventing bio-film formation and surface degradation.

  • Marine Antifouling: Provides effective non-organotin biocide protection against barnacles, soft fouling, and macro-algae.
  • Dry-Film Protection: Protects wall coatings in high-humidity tropical microclimates from black mold growth (*Aspergillus niger*).

Plastics, PVC & Polyurethane (PU)

Polymer degradation due to fungal colonisation causes discoloration, unpleasant odors, and structural embrittlement in outdoor PVC, EVA, and PU products.

  • Applications: PVC flooring, synthetic leather, roofing membranes, shower curtains, and outdoor seating.
  • Thermal Stability: ZPT maintains structural integrity during polymer extrusion up to temperatures of 200°C without degassing or loss of biocidal efficacy.

Technical Roadmap & Future Innovations in Pyrithione Chemistry

Strategic R&D initiatives aimed at enhancing sustainability, bioavailability, and regulatory compliance.

Micro-Encapsulation & Controlled Release

Developing silica micro-encapsulated ZPT grades to minimize direct cutaneous penetration while extending biocidal delivery over prolonged wash cycles. Micro-encapsulation also mitigates discoloration risks when formulated alongside free iron ions in complex personal care matrices.

Synergistic Anti-Dandruff Blends

To comply with evolving regional regulation thresholds, technical developments focus on multi-active synergies. Combining reduced ZPT dosages with secondary actives such as Climbazole, Piroctone Olamine, or Scalp-calming botanical extracts maintains clinical efficacy while lowering toxicological footprints.

Eco-Friendly Catalytic Synthesis

JIMPOCHEM's R&D hub in Jinan is implementing atom-economic synthetic routes that eliminate organic halogenated solvents during pyridine oxidation, resulting in cleaner effluent profiles, lower volatile organic compound (VOC) emissions, and zero heavy-metal carryover.

China Supply Chain Resilience & Manufacturing Efficiency

Strategic logistical capabilities, raw material integration, and global dispatch stability.

Upstream Feedstock Integration

Our strategically situated facilities in Shandong's Jinan Chemical Park benefit from direct pipeline and local integration of key precursors (2-Chloropyridine and Sodium Hydrosulfide). This upstream integration protects international buyers from global market price spikes and supply disruptions.

Scalable Custom Manufacturing

Operating across 500+ acres with digitalized batch control systems, we seamlessly scale operations from multi-ton industrial trial batches to continuous metric-ton global supply streams, maintaining batch-to-batch chemical homogeneity.

Global Logistics Infrastructure

Proximity to Qingdao Port and major logistics networks enables efficient containerized transport under strict dangerous goods (DG) packing regulations. Standardized ISO-tank and UN-certified drum packaging ensure safe transoceanic transit.

Global Regulatory Framework & Technical Compliance Support

Navigating global biocidal directives, cosmetic regulations, and safety standards.

Compliance is paramount when introducing active biocides into international retail supply chains. JIMPOCHEM delivers full regulatory technical dossiers for customer audit:

EU Cosmetic Regulation & BPR

Following updates under Regulation (EC) No 1223/2009 regarding ZPT classification in leave-on cosmetics within the European Union, JIMPOCHEM offers specialized compliant guidance for industrial biocide applications covered under the Biocidal Products Regulation (BPR, Regulation (EU) No 528/2012).

US EPA & FDA Standards

For US markets, our Zinc Omadine grades align with US EPA FIFRA requirements for structural antimicrobial surface coatings and non-food contact polymers, as well as OTC monograph guidelines where applicable.

Full Analytical Dossier

Every shipment is accompanied by detailed Certificates of Analysis (COA), HPLC purity assays, heavy metal ICP-MS testing reports, particle size distribution curves, Safety Data Sheets (SDS), and REACH registration support.

Specialty Chemical Product Portfolio & Industry Application Spectrum

Integrated solutions spanning pharmaceuticals, daily cosmetics, rubber/plastics, electronics, and coatings.

Daily Chemical Industry

Cosmetics, makeup, perfume, facial cleansers, hand sanitizers, body wash, toothpaste, and detergents. Featured actives include Zinc Pyrithione (CAS 13463-41-7), PPG-20 Methyl Glucose Ether (CAS 61849-72-7), Lauryl Hydroxysultaine (CAS 13197-76-7), Sodium Phytate (CAS 14306-25-3), and Bemotrizinol (CAS 187393-00-6).

Pharmaceutical Industry

Production of active pharmaceutical ingredients (API), pharmaceutical excipients, intermediates, solvents, catalysts, reactants, and medical anesthesia raw materials. Highlights include Tris Base (CAS 77-86-1), Glutathione (CAS 70-18-8), Polydeoxyribonucleotide PDRN (CAS 100403-24-5), and Benzethonium Chloride (CAS 121-54-0).

Rubber, Plastics & Coatings

Packaging, automotive parts, tire manufacturing, industrial seals, architectural/decorative coatings, and printing inks. Active additives include 4-Chloro-3,5-dimethylphenol PCMX (CAS 88-04-0), Dibenzoylmethane (CAS 120-46-7), and Calcium Acetylacetonate (CAS 19372-44-2).

Electronics & New Energy Industry

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Factory Tour & Facility Infrastructure

A glimpse inside JIMPOCHEM's 500-acre modern production base, laboratory R&D centers, advanced equipment, and packaging lines.

Technical & Commercial FAQ (Q&A)

Direct answers to key questions from formulation engineers, regulatory specialists, and procurement teams.

Q1: What is the primary chemical distinction between Zinc Omadine (ZPT) dispersion and ZPT powder?
Zinc Omadine Powder (98%+ active) is a crystalline solid ideal for dry polymer compounding, masterbatches, and chemical synthesis. ZPT 48% Aqueous Dispersion is a micro-milled colloidal suspension specifically stabilized with viscosity modifiers for immediate incorporation into liquid personal care formulations (shampoos, body washes) and water-based industrial latex paints.
Q2: How does particle size distribution ($D_{50}$) affect performance in anti-dandruff shampoos?
Optimal antimicrobial efficacy requires a controlled $D_{50}$ particle size between 1.2 µm and 1.8 µm. Smaller particle sizes ensure uniform spatial distribution across the scalp during washing and optimize retention in follicular openings, maximizing fungicidal action against *Malassezia* while preventing rapid sedimentation during shelf storage.
Q3: How to prevent discoloration in formulations containing free iron ions?
Zinc Pyrithione reacts with trace ferric ions ($Fe^{3+}$) to form insoluble, intensely blue-colored iron pyrithione complexes. To prevent discoloration in water-based formulations, formulators should add chelating agents such as Sodium Phytate (CAS 14306-25-3) or Tetrasodium EDTA prior to ZPT introduction, or utilize encapsulated ZPT grades.
Q4: What certifications and regulatory compliance documents does JIMPOCHEM provide?
JIMPOCHEM operates under ISO 9001 and ISO 14001 certified quality management systems. Every Zinc Omadine batch includes a COA detailing assay, pH, particle size, and heavy metal impurity levels. Full Safety Data Sheets (SDS compliant with GHS/CLP), REACH compliance documentation, and toxicity summaries are readily accessible.

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