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An exhaustive technical dossier on physical-chemical metrics, reactive pathways, and high-performance industrial applications.
O-Phthalaldehyde (often abbreviated as OPA, CAS Number: 643-79-8) is a aromatic dialdehyde compound represented by the chemical formula C8H6O2 (1,2-Benzenedicarboxaldehyde). Featuring two adjacent formyl groups attached directly to a benzene ring, OPA exhibits exceptional reactivity toward primary amines, thiols, and biological macromolecules.
Unlike traditional mono-aldehydes or glutaraldehyde, the rigid ortho-configuration of the dialdehyde functions allows OPA to form stable cyclic adducts (isoindoles) upon reaction with amino acids and proteins. This unique stereochemistry underpins both its microbicidal potency and its utility in high-sensitivity fluorometric analytics.
Industrial scale production of O-Phthalaldehyde requires stringent control over oxidation pathways to prevent over-oxidation to phthalic acid. China's leading chemical facilities utilize two primary synthesis routes:
Modern production at JIMPOCHEM incorporates continuous crystallization technology, yielding an ultra-pure white crystalline powder with ≥99.5% purity (HPLC) and minimal residual trace metals.
| Property Parameter | Technical Specification Value | Testing Method Standard |
|---|---|---|
| CAS Registry Number | 643-79-8 | EINECS: 211-402-2 |
| Appearance | Light yellow to off-white crystalline solid | Visual Inspection |
| Assay (Purity) | ≥ 99.0% (Standard Grade) / ≥ 99.5% (High-Purity Grade) | HPLC (High-Performance Liquid Chromatography) |
| Melting Point | 54.0 °C to 57.0 °C | Capillary Tube Melting Point Apparatus |
| Solubility Profile | Soluble in Water (moderate), Ethanol, Ether, Isopropanol | Gravimetric / Visual Solubilization |
| Loss on Drying | ≤ 0.5% | Vacuum Drying at 40°C for 4 Hours |
| Residue on Ignition | ≤ 0.1% | Sulfated Ash Analysis (USP <281>) |
| Heavy Metals (as Pb) | ≤ 10 ppm | Atomic Absorption Spectroscopy (AAS) |
Global designated chemical service provider delivering high-end fine chemicals and tailored supply chain solutions.
JIMPOCHEM CO., LTD was established in 2010 and is headquartered in the Chemical Industry Park of Jinan City, Shandong Province. The company covers an area of over 500 acres and operates as a professional chemical raw material manufacturer integrating research and development, continuous production, international sales, and advanced technical services.
Our core focus centers on high-end fine chemicals, biocide active ingredients, diagnostic reagents, and cosmetic raw materials. Having obtained multiple global certifications—including ISO 9001 Quality System and ISO 14001 Environmental Management System—JIMPOCHEM is committed to empowering global enterprises through high-purity chemical raw materials and one-stop procurement solutions.
Deploying O-Phthalaldehyde across medical, analytical, pharmaceutical, and industrial domains.
O-Phthalaldehyde is internationally recognized as a premier High-Level Disinfectant (HLD) for heat-sensitive reusable medical instruments, specifically flexible endoscopes, bronchoscopes, and surgical equipment.
Formulated at a standard 0.55% buffered aqueous solution, OPA delivers complete destruction of Mycobacterium tuberculosis, Pseudomonas aeruginosa, hepatitis viruses, and HIV within a rapid 12-minute immersion time at 20°C. OPA solutions exhibit superior material compatibility with stainless steel, titanium, silicone, aluminum, and polyurethane compared to acidic peracetic acid or volatile glutaraldehyde.
In analytical laboratories, OPA serves as a golden-standard reagent for pre-column and post-column fluorometric derivatization of primary amino acids, peptides, and amine-containing neurotransmitters in HPLC and capillary electrophoresis.
In the presence of nucleophilic thiols (such as 3-mercaptopropionic acid or 2-mercaptoethanol), OPA reacts within seconds to form intense fluorescent isoindole derivatives with excitation around 340 nm and emission at 450 nm, permitting picomole-level quantitative detection in clinical bioassays.
OPA serves as a versatile bi-functional building block in organic synthesis. It is extensively utilized as a key starting material (KSM) or intermediate for producing:
JIMPOCHEM delivers customized mesh sizes, controlled moisture levels, and tailored packaging to meet strict cGMP drug master file (DMF) requirements.
Beyond clinical healthcare, OPA-based biocidal formulations are increasingly integrated into specialized industrial applications, including high-tech semiconductor process water control, membrane bio-fouling mitigation, and closed-loop cooling towers.
Its fast-acting mode of cross-linking cellular wall proteins renders micro-organisms incapable of developing genetic resistance, making it an ideal rotational biocide for critical contamination control.
Why top-tier global pharmaceutical and chemical buyers choose JIMPOCHEM as their designated partner.
Leveraging years of industry integration, JIMPOCHEM has established robust raw material procurement channels and partnerships with leading chemical suppliers. Our modern Jinan production base employs automated intelligent control systems, balancing massive scale output with flexible custom batch manufacturing.
Adhering to the principle that "Quality is the lifeline of an enterprise," every batch undergoes rigorous standard testing from raw material entry to final delivery. Our end-to-end batch traceability system allows customers to trace raw material origins, reaction logs, analytical COA spectra, and logistics handling via unique QR batch codes.
In response to global "dual-carbon" environmental goals, JIMPOCHEM has engineered closed-loop solvent recovery units and multi-stage catalytic waste gas incinerators. Our sustainable processes minimize waste generation, helping downstream partners achieve green supply chain compliance.
Navigating international regulatory frameworks with full authorization and legal documentation.
Exporting high-purity chemical raw materials across North America, Europe, and Asia-Pacific demands stringent regulatory compliance. JIMPOCHEM provides a complete compliance file with every shipment:
Due to the sensitivity of dialdehydes to heat and light, O-Phthalaldehyde requires specialized packaging to prevent polymerisation or degradation during ocean/air transportation:
Pioneering green catalytic innovations and next-generation chemical purity standards.
Transitioning traditional batch stirred tank reactors (STR) to continuous micro-fluidic flow reactors. This technology reduces reaction residence time from hours to seconds, significantly minimizing side reactions and elevating crude product purity to >99.7% prior to crystallization.
Co-developing advanced micro-encapsulated OPA matrices for medical disinfectant applications to further reduce vapor pressure, eliminate olfactory irritation for hospital staff, and extend solution bath shelf-life beyond 28 days.
Investing in eco-friendly bio-mimetic oxidation catalysts that eliminate heavy metal residues altogether, catering to ultra-clean semiconductor biocide formulations and bio-analytical reagents.
State-of-the-art production equipment, R&D laboratories, and automated packaging lines.
Expert responses addressing common procurement, technical, and handling inquiries regarding CAS 643-79-8.
Discover complementary chemical intermediates and specialized raw materials manufactured by JIMPOCHEM.
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