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N-(3-Aminopropyl)morpholine, frequently abbreviated as N-APM or APM (CAS: 123-00-2, EINECS: 204-590-2), represents a pivotal heterocyclic primary amine containing a tertiary morpholine ring structure. Chemically defined as 4-morpholinepropanamine or 3-(morpholin-4-yl)propan-1-amine with the molecular formula C7H16N2O and a molecular weight of 144.21 g/mol, this versatile liquid organic compound functions as an essential building block, curing promoter, and chemical intermediate across global manufacturing sectors.
Due to its unique dual-functionality—combining a reactive primary amine group ($\text{-NH}_2$) at one end with a stable, basic tertiary amine ether structure (the morpholine ring) at the other—N-(3-Aminopropyl)morpholine exhibits exceptional nucleophilic reactivity, thermal stability, and catalytic performance. It acts as an invaluable crosslinking modifier in epoxy resins, an effective polyurethane catalyst, a robust industrial corrosion inhibitor, and a core precursor for pharmaceutical APIs and crop-protection chemicals.
| Chemical Parameter | Guaranteed Specification Standard | Typical Factory Batch Result | Analytical Test Method |
|---|---|---|---|
| Chemical Name | N-(3-Aminopropyl)morpholine / APM | 4-Morpholinepropanamine | IUPAC Standard |
| CAS Registry Number | 123-00-2 | 123-00-2 | CAS Verification |
| Assay / Purity (GC) | $\ge 99.5\%$ (Industrial Grade) | 99.82% | Gas Chromatography (FID) |
| Appearance | Clear, colorless to light yellow liquid | Colorless Transparent Liquid | Visual Inspection |
| Water Content (Karl Fischer) | $\le 0.20\%$ | 0.08% | ASTM E203 (KF Titration) |
| Color Scale (APHA) | $\le 30$ Platinum-Cobalt | 10 APHA | ASTM D1209 |
| Boiling Point Range | 222.0 °C – 226.0 °C at 760 mmHg | 224.2 °C | Distillation Range Test |
| Density ($20^\circ\text{C}$) | 0.985 – 0.995 g/cm³ | 0.989 g/cm³ | Pycnometer Method |
| Refractive Index ($n_D^{20}$) | 1.4740 – 1.4780 | 1.4762 | Refractometry |
| Flash Point | 98.0 °C (Closed Cup) | 99.5 °C | ASTM D93 |
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Understanding the demand drivers for N-(3-Aminopropyl)morpholine across modern high-tech industries.
The global demand for N-(3-Aminopropyl)morpholine is expanding rapidly, driven primarily by high-performance epoxy resin formulations used in wind turbine blade composites, automotive structural adhesives, electronic encapsulants, and heavy-duty protective marine coatings. Furthermore, the chemical’s ability to neutralize acid gas components makes it indispensable in petroleum refining and gas-sweetening processes.
As international regulations demand longer-lasting, corrosion-resistant infrastructure and lower VOC coatings, formulators are shifting toward specialized aliphatic amine adducts. N-APM serves as a critical reactive precursor that imparts flexible chain segments, rapid ambient temperature curing capability, and superior chemical resistance to finalized resin networks.
JIMPOCHEM operates dedicated chemical reaction trains within the Chemical Industry Park of Jinan City, Shandong Province. Our production of N-(3-Aminopropyl)morpholine utilizes a high-efficiency continuous catalytic process:
Adhering to our core philosophy that "Quality leads the future," JIMPOCHEM enforces a multi-tiered quality control protocol:
Explore how N-(3-Aminopropyl)morpholine transforms industrial chemistry across 5 primary application vectors.
N-APM acts as a potent room-temperature curing agent or accelerator for epoxy resins (Bisphenol A and Bisphenol F types). The primary amine group participates directly in epoxide ring-opening, while the tertiary amine ring exerts a catalytic effect on self-polymerization.
Benefits: Imparts high thermal distortion temperatures (HDT), exceptional impact resistance, excellent moisture barrier properties, and superior adhesion to metal substrates. Ideal for wind turbine blades, heavy-duty floor coatings, and electrical potting compounds.
In polyurethane (PU) manufacturing, N-(3-Aminopropyl)morpholine functions as a blow/gel balance catalyst. Its tertiary nitrogen atom accelerates the reaction between polyols and soft/hard segment isocyanates (MDI/TDI).
Benefits: Promotes uniform microcellular cell structures in rigid foam insulation panels and flexible automotive seating, reducing shrinkage and eliminating surface pinholes.
Due to its alkaline nature and surface-active amine head group, N-APM forms durable protective hydrophobic monomolecular films on metallic surfaces in steam boilers, condensate return lines, and closed-loop cooling towers.
Benefits: Prevents carbonic acid corrosion and oxygen pitting in steel pipelines, dramatically extending infrastructure lifespan in power plants and petrochemical refineries.
The morpholine ring moiety is a key pharmacophore present in many biologically active molecules. N-APM is routinely used as a high-purity synthetic intermediate for bactericides, fungicides, analgesics, and active pharmaceutical ingredients (APIs).
Benefits: Ensures predictable reaction yields with high purity ($>99.5\%$), avoiding side reactions during complex multi-step organic synthesis.
By reacting the primary amine of N-APM with fatty acids, manufacturers produce specialty amphoteric surfactants, emulsifiers, and antistatic agents utilized in textile treatment, personal care formulations, and industrial cleaners.
Benefits: Enhances emulsification stability, provides mild conditioning properties, and lowers surface tension in water-based formulations.
In response to global carbon-neutral directives and environmental sustainability targets, JIMPOCHEM has implemented green engineering upgrades across our Shandong production base:
When sourcing N-(3-Aminopropyl)morpholine internationally, chemical buyers should evaluate key procurement parameters beyond simple unit cost:
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JIMPOCHEM CO., LTD was established in 2010 and is headquartered in the Chemical Industry Park of Jinan City, Shandong Province. The company covers an area of over 500 acres and is a professional chemical raw material manufacturer that integrates research and development, production, sales, and technical services. Its core focus is on high-end fine chemicals, fluorine compounds, organic intermediates, and cosmetic raw materials.
We have obtained multiple product-related certifications, including ISO quality system certification and environmental management system certification, and are committed to providing high-quality chemical products and one-stop procurement service solutions to global customers.
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