High-purity intermediate standards, fine organic compounds, and industrial solutions manufactured under cGMP compliance.
An essential C-2 epimer of D-glucose playing a pivotal role in bio-manufacturing, targeted therapeutic formulations, and cell culture glycobiology.
D-(+)-Mannose (Formula: $\text{C}_6\text{H}_{12}\text{O}_6$, CAS: 3458-28-4), also systematically identified as D-Mannopyranose, is a hexose monosaccharide that serves as a vital structural unit in eukaryotic carbohydrate biochemistry. As the C-2 epimer of D-glucose, D-mannose exhibits distinct physical and chemical attributes, notably its specific optical rotation, sweetness profile, and conformational kinetics in aqueous equilibrium.
Under ambient conditions, D-mannose crystallizes into an α- and β-anomeric mixture, with the α-D-mannopyranose form predominating in solid-state synthesis. Its pivotal role in human physiological functions—specifically N-linked glycosylation of proteins—makes it a high-value active pharmaceutical ingredient (API) building block, dietary therapeutic, and cosmetic moisture-retention factor.
JIMPOCHEM enforces rigorous quality metrics for enterprise procurement, surpassing USP, EP, and JP monograph standards. Our manufacturing process delivers high-purity crystalline powder optimized for rapid dissolution and minimal endotoxin load.
• Assay Purity: $\ge 99.0\%$ (HPLC, Dry Basis)
• Specific Optical Rotation $[\alpha]_D^{20}$: $+14.0^\circ \text{ to } +15.3^\circ$
• Heavy Metals Total: $\le 5\text{ ppm}$ | Lead $\le 0.1\text{ ppm}$
• Bacterial Endotoxins: $< 0.1\text{ EU/mg}$ (Injectable Grade Available)
| Parameter / Specification | Standard Enterprise Grade | Pharma / Bio-Grade Specification | Test Analytical Methodology |
|---|---|---|---|
| Chemical Name | D-(+)-Mannose / D-Mannopyranose | D-(+)-Mannose Ultra Pure | IUPAC Nomenclature |
| CAS Registry Number | 3458-28-4 | 3458-28-4 | CAS Verification |
| Appearance | White Crystalline Powder | White Free-flowing Crystals | Visual Inspection |
| Assay Purity (HPLC) | 98.5% – 100.5% | $\ge 99.5\%$ (HPLC area) | High-Performance Liquid Chromatography |
| Loss on Drying | $\le 0.5\%$ | $\le 0.2\%$ | Vacuum Drying at 105°C |
| Residue on Ignition (Ash) | $\le 0.1\%$ | $\le 0.05\%$ | USP <281> Gravimetric |
| Melting Point Range | 128°C – 134°C | 131°C – 133°C | Capillary Melting Apparatus |
| Microbial Total Viable Count | $\le 1000\text{ CFU/g}$ | $\le 100\text{ CFU/g}$ (Sterile options) | Microbiological Plate Count |
Analyzing global consumption shifts across biotherapeutics, non-antibiotic UTI preventatives, and green enzymatic chemical routes.
The global shift away from prophylactic antibiotic use in recurrent Urinary Tract Infections (rUTIs) has propelled D-Mannose to the forefront of functional nutraceuticals. Clinical evidence confirming D-mannose’s competitive binding affinity to *E. coli* Type 1 fimbriae (FimH lectin) has driven an estimated global market CAGR of 7.4% in the nutraceutical sector.
In biopharmaceutical downstream processing, high-purity D-mannose is increasingly utilized as a media supplement to modulate antibody glycosylation profiles. Recombinant monoclonal antibodies (mAbs) require precise mannose feeding regimes to ensure consistent effector function, antibody-dependent cellular cytotoxicity (ADCC), and extended serum half-life.
Traditional chemical extraction of D-mannose via plant polysaccharide acid hydrolysis is rapidly being replaced by multi-enzyme immobilized biotransformation from D-glucose or D-fructose. This technological leap dramatically reduces chemical waste, improves atom economy, and guarantees freedom from plant-derived allergen contaminants.
From therapeutic dosage forms to high-end cosmetic bio-actives, discover how D-mannose serves modern industrial pipelines.
D-Mannose is widely formulated into sachets, chewable tablets, hard capsules, and liquid syrups. Its therapeutic action relies on saturating bacterial lectins, preventing *Uropathogenic Escherichia coli* (UPEC) from adhering to the urothelium lining, thereby facilitating natural urinary clearance.
In topical dermatological applications, D-mannose serves as a specialized prebiotic agent. It selectively feeds beneficial skin flora while down-regulating opportunistic pathogen colonization, thereby strengthening the skin barrier function and supporting natural hydration retention.
As a critical raw material in cell culture media, low-endotoxin D-mannose enables precise control over high-mannose glycan structures during recombinant protein synthesis in mammalian expression systems (e.g., CHO cell lines).
With global bans on prophylactic growth-promoting antibiotics in livestock feed, D-mannose derivatives and pure mannose additions support gut health in swine, poultry, and aquaculture by binding pathogenic enteric bacteria in the intestinal tract.
A Premier Fine Chemical & Bio-Ingredient Manufacturer Driving Innovation, Quality, and Global Supply Chain Excellence Since 2010.
JIMPOCHEM CO., LTD was established in 2010 and is headquartered in the prestigious Chemical Industry Park of Jinan City, Shandong Province. Covering an expansive footprint of over 500 acres, the company is a fully integrated chemical enterprise synthesizing high-end fine chemicals, pharmaceutical raw materials, bio-monosaccharides, and cosmetic active ingredients.
Under strict ISO 9001 quality management, ISO 14001 environmental management, and ISO 45001 occupational safety systems, JIMPOCHEM operates modern automated synthesis lines and continuous crystallization systems. Our commitment to high purity, full batch traceability, and regulatory transparent documentation has earned us designated supplier status with leading multinational pharmaceutical and nutraceutical corporations.
• Intelligent Production & Scale: Distributed Control Systems (DCS) ensure precise reaction parameters, enabling robust multi-ton batch scalability with zero compromise on analytical purity.
• Rigorous Quality Control: Advanced analytical centers equipped with HPLC-MS, GC-MS, FT-IR, ICP-MS, and polarimetry equipment perform full-spectrum testing on every lot before dispatch.
• Dual-Carbon & Sustainability Focus: Biocatalytic enzymatic routes reduce energy consumption by 40% and minimize organic effluent, facilitating client compliance with global ESG mandates.
Ensuring seamless international procurement through global regulatory certifications and strategic regional distribution network hubs.
Navigating global chemical and dietary additive regulations requires complete documentation packages. JIMPOCHEM supports global client registration by providing:
To preserve optical purity and prevent hygroscopic clumping during transit, D-mannose products are packaged in specialized multi-layer moisture-barrier containment:
Leveraging proximity to major international shipping ports in China (Qingdao, Tianjin, Shanghai), JIMPOCHEM guarantees optimized maritime and air freight routes:
Advancing the boundaries of enzymatic synthesis, continuous crystallization engineering, and ultra-pure glycobiology grades.
JIMPOCHEM’s R&D division is developing third-generation engineered D-mannose isomerases with elevated thermal stability and superior substrate conversion efficiency. By optimizing enzyme recycling loops, our next-generation bioprocess aims to reduce carbon emissions per metric ton produced by an additional 25% by 2026.
To support expanding applications in cell-based therapies and parenteral formulations, JIMPOCHEM is expanding its dedicated cleanroom crystallization lines (Class 100,000 / ISO 8). This facility expansion will deliver injectable-grade D-mannose with endotoxin levels strictly controlled below 0.05 EU/mg.
Technical and procurement insights tailored for chemical buyers, quality assurance teams, and formulation engineers.
Explore additional high-grade chemical raw materials and industrial intermediates available for global delivery.
JIMPOCHEM