Direct Factory Supply from China's Premier Chemical Park Facilities
Benzethonium Chloride (trade name Hyamine 1622) is a synthetic quaternary ammonium salt exhibiting exceptional antimicrobial, surfactant, and antiseptic properties. Chemically designated as N,N-dimethyl-N-[2-[2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy]ethyl]benzenemethanaminium chloride, this cationic surfactant disruptively interacts with microbial cell membranes, leading to cytoplasmic leakage and rapid cell lysis. Global formulators across pharmaceutical, personal care, and industrial sanitation sectors rely heavily on Chinese manufacturing facilities for consistent, USP/EP/BP compliant grades.
Key Technical Insight: Benzethonium Chloride maintains biological efficacy across a broad pH spectrum (pH 4.0 to 10.0), demonstrating superior thermal stability compared to conventional halogenated or phenolic preservatives. Its cationic nature renders it highly compatible with non-ionic surfactants and amphoteric systems.
| Property Parameter | USP Grade Technical Standard | EP / BP Grade Standard | Industrial High-Purity Grade |
|---|---|---|---|
| CAS Number | 121-54-0 | 121-54-0 | 121-54-0 |
| Molecular Formula | C27H42ClNO2 | C27H42ClNO2 | C27H42ClNO2 |
| Assay (Purity Titration) | 99.0% – 101.0% (Dried Basis) | 99.0% – 101.0% | ≥ 98.5% |
| Appearance | White crystalline powder | White to off-white powder | White crystalline powder |
| Melting Point Range | 158°C – 164°C | 159°C – 163°C | 156°C – 164°C |
| Heavy Metals (as Pb) | ≤ 10 ppm | ≤ 10 ppm | ≤ 20 ppm |
| Loss on Drying | ≤ 5.0% | ≤ 5.0% | ≤ 5.5% |
| Residue on Ignition | ≤ 0.1% | ≤ 0.1% | ≤ 0.2% |
The positively charged quaternary nitrogen head group binds tightly to negatively charged lipopolysaccharides and phospholipids on bacterial membrane surfaces.
The long non-polar octylphenoxyethoxyethyl chain inserts into the lipid bilayer, destabilizing normal membrane fluidity and permeability controls.
Irreversible disruption leads to cellular leakage of low-molecular-weight metabolites, essential ions (K+ and Mg2+), and enzymatic denaturation.
China has established itself as the global hub for fine chemical synthesis, leveraging fully integrated petrochemical value chains, advanced process engineering, and rigorous environmental management infrastructure. Facilities operating within chemical industry parks—such as JIMPOCHEM’s 500-acre complex in Shandong Province—offer global procurement managers distinct strategic advantages.
Direct sourcing of key intermediates (4-octylphenol and ethylene oxide) minimizes raw material price volatility and guarantees steady batch outputs.
Fully automated Distributed Control Systems monitor reaction kinetics, quaternization temperature, and crystallization cycles to prevent side-product formation.
Advanced MVR evaporation and catalytic oxidizers ensure complete wastewater and off-gas treatment aligned with dual-carbon green manufacturing targets.
Multi-metric-ton production capacities support bulk spot orders and custom multi-ton annual contract fulfillments with minimal lead time.
Benzethonium Chloride Antiseptic is recognized by regulatory bodies worldwide for its versatile functionality across healthcare, personal hygiene, and industrial processing. Formulators leverage its biocide profile as an active pharmaceutical ingredient (API), topical antiseptic, preservative, and anti-odor agent.
Used extensively in first-aid antiseptic sprays, wound wash solutions, burn creams, and anti-itch liquids at concentrations ranging from 0.1% to 0.2%. Under US FDA OTC monographs (21 CFR Part 333), Benzethonium Chloride serves as a safe and effective skin protectant and topical antimicrobial agent. Its rapid kill time against *Staphylococcus aureus* and *Pseudomonas aeruginosa* ensures sterile surgical site preparation.
Acts as an anti-acne agent, deodorant ingredient, and broad-spectrum preservative in high-end cosmetics. Incorporated into leave-on and rinse-off formulations, moist wet wipes, hand cleansers, and alcohol-free sanitizers. It offers non-staining, non-stinging benefits compared to traditional isopropyl alcohol solutions, protecting sensitive skin matrices.
Formulated into anti-plaque oral rinses, anti-gingivitis mouthwashes, and gargle sprays. Benzethonium Chloride controls oral bio-films and reduces *Streptococcus mutans* colonization without altering taste perception or staining teeth enamel when dosed within therapeutic micro-concentrations.
Deployed in veterinary sanitation, cleanroom hard-surface fogging, and food processing plant equipment sanitizers. Its residual bactericidal film prevents bio-fouling on stainless steel, glass, and polymer polymers without accelerating surface corrosion.
Global pharmaceutical and cosmetics procurement requires absolute compliance with international regulatory frameworks. Leading Chinese manufacturers prioritize complete audit-readiness and batch-to-batch traceability.
Full support for customer registration dossiers, including US FDA Drug Master Files (DMF), EU REACH registration, cosmetic ingredient safety data (CSRP), and ISO 9001/14001/45001 certificates.
Every commercial batch undergoes multi-stage Quality Control testing using calibrated High-Performance Liquid Chromatography (HPLC), Gas Chromatography for residual solvents, ICP-MS for heavy metals, and microbiological assay validation.
Integrated QR-coded batch tracking systems enable seamless audit trails from basic chemical reagents to final packaged drums, guaranteeing complete accountability and immediate third-party verification.
Designated Chemical Service Provider — Quality Leads the Future
JIMPOCHEM CO., LTD was established in 2010 and is headquartered in the Chemical Industry Park of Jinan City, Shandong Province. The company covers an area of over 500 acres and is a professional chemical raw material manufacturer that integrates research and development, production, sales, and technical services. Its core focus is on high-end fine chemicals and cosmetic raw materials.
We have obtained multiple product-related certifications, including ISO quality system certification and environmental management system certification. Our core team comprises experts with over 10 years of experience in the chemical industry, enabling us to provide customized solutions in product development, formula optimization, and supply chain management.
As a designated chemical service provider, we maintain strategic partnerships with globally renowned chemical enterprises across Europe, America, Southeast Asia, the Middle East, and Oceania.
When purchasing Benzethonium Chloride Antiseptic on an industrial scale, procurement officers should evaluate critical technical factors beyond nominal pricing to avoid downstream formulation failures.
High-grade Benzethonium Chloride yields completely crystal-clear 10% aqueous solutions with zero turbidity, insoluble particulates, or residual coloration—vital for clear cosmetic gels and oral rinses.
Unreacted alkyl halides or free amines cause discoloration and odor over time. Modern crystallization technology isolates target molecules, ensuring long-term shelf stability of finished products.
Standard packaging includes UN-approved 25kg fiber drums with dual inner PE bags. Store in sealed containers in a cool, dry, well-ventilated area away from strong oxidizing agents and anionic surfactants.
The global demand for effective antiseptics continues to expand alongside heightened hygiene standards and cosmetic formulation evolution. Key technical trends shaping the Benzethonium Chloride market include:
Formulators increasingly combine low-dose Benzethonium Chloride with chelating agents (such as Sodium Phytate or Disodium EDTA) and booster glycol solvents (e.g., 3-Methoxy-3-Methyl-1-Butanol) to lower overall active concentration while amplifying broad-spectrum antimicrobial activity.
Due to alcohol-induced dermal irritation and flammable hazardous transport constraints, ethanol-free hand sanitizers utilizing Benzethonium Chloride are rapidly replacing traditional alcohol rubs in institutional healthcare and consumer wipes.
Expert Guidance on Benzethonium Chloride Sourcing, Safety, and Formulations
While both are quaternary ammonium antiseptics, Benzethonium Chloride possesses a defined synthetic chemical structure with a specific phenoxyethoxyethyl hydrophobic chain. Benzalkonium Chloride is a mixture of alkylbenzyldimethylammonium chlorides with varying alkyl chain lengths (C12–C16). Benzethonium Chloride typically exhibits greater batch-to-batch purity and structural consistency for pharmaceutical applications.
In the United States, Benzethonium Chloride is monographed under FDA 21 CFR Part 333 for OTC topical antimicrobial products. In Europe, it is regulated under the EU Cosmetics Regulation EC 1223/2009 (Annex V) and REACH. China’s NMPA permits its usage in specified rinse-off and leave-on personal care products under designated threshold concentration guidelines.
No. As a cationic surfactant, Benzethonium Chloride is incompatible with strongly anionic surfactants (such as Sodium Lauryl Sulfate or Sodium Laureth Sulfate), which cause precipitation and neutralization of antimicrobial activity. It is fully compatible with non-ionic surfactants, amphoteric surfactants (like Lauryl Hydroxysultaine), and cationic emulsifiers.
Benzethonium Chloride powder should be stored in tightly sealed original containers, protected from moisture, light, and direct heat. When stored below 30°C in dry cleanroom conditions, the typical shelf life exceeds 24 months without loss of purity or antimicrobial potency.
Yes. Leveraging our 500-acre manufacturing base and R&D laboratory, JIMPOCHEM provides custom particle sizing (milling/micronization), solution pre-dilutions, custom packaging solutions, and OEM contract manufacturing tailored to client technical requirements.
Buyers can request full documentation—including Certificate of Analysis (COA), Safety Data Sheet (SDS), and lab testing samples—by contacting our technical sales team directly through our website product portal or inquiry links.
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