High-yield, lab-tested chemical precursors and fine cosmetics ingredients manufactured under strict international quality controls.
Comprehensive technical insights into Azelaic Acid (CAS 123-99-9) mechanisms, bio-synthesis routes, dermatological therapeutics, and global procurement strategies.
Azelaic acid functions as a robust anti-inflammatory agent through multi-targeted biochemical pathways. It significantly downregulates the transcription of pro-inflammatory cytokines, specifically Interleukin-1β (IL-1β), Interleukin-6 (IL-6), and Tumor Necrosis Factor-alpha (TNF-α), by modulating nuclear factor kappa B (NF-κB) activation within epidermal keratinocytes and dermal fibroblasts.
As a potent scavenger of reactive oxygen species (ROS), Azelaic Acid halts neutrophil-mediated oxidative cascades. By suppressing hydroxyl radicals (•OH) and superoxide anions (O2-), it prevents lipid peroxidation within cell membranes, reducing inflammation in conditions such as papulopustular rosacea, vulgaris acne, and erythema post-acne inflammatory hyperpigmentation.
Recent clinical studies demonstrate Azelaic Acid’s ability to inhibit Kallikrein-5 (KLK5) serine protease gene expression. This suppression prevents the proteolytic cleavage of cathelicidin into LL-37 peptides—the primary biochemical trigger for skin inflammation, vascular hyperreactivity, and telangiectasia in rosacea sufferers.
| Parameter / Parameter Name | Cosmetic Grade Standard | Pharmaceutical (USP/EP) Grade | Test Method / Protocol |
|---|---|---|---|
| Chemical Structure / CAS | HOOC-(CH2)7-COOH / CAS 123-99-9 | HPLC / NMR Verification | |
| Purity / Assay (Dry Basis) | ≥ 98.5% | ≥ 99.5% | Titration / HPLC |
| Appearance | White to Off-White Fine Powder | Pure White Crystalline Powder | Visual Inspection |
| Melting Point Range | 105.0°C – 110.0°C | 106.5°C – 109.0°C | Capillary Tube / DSC |
| Particle Size Distribution | Microfine (D90 < 20 μm) | Ultra-Micronized (D90 < 10 μm) | Laser Diffraction (Malvern) |
| Heavy Metals (as Pb) | ≤ 10 ppm | ≤ 5 ppm | ICP-MS |
| Residue on Ignition | ≤ 0.1% | ≤ 0.05% | Gravimetric Analysis |
Analyzing traditional ozonolysis versus next-generation bio-catalytic catalytic oxidation pathways developed at JIMPOCHEM's 500-acre modern production base.
The classical industrial route cleaves oleic acid at the double bond via ozone gas followed by oxidative workup, yielding Azelaic Acid and Pelargonic Acid (Nonanoic acid). While high yield, traditional ozonolysis generates volatile byproducts and safety hazards requiring intensive fractionation and continuous loop reactors.
JIMPOCHEM utilizes hydrogen peroxide (H2O2) with transition metal catalysts (Tungsten/Cobalt-based complexes) to oxidize ricinoleic acid derivatives or castor oil bio-feedstocks. This eco-friendly process dramatically reduces carbon footprint, minimizes hazardous emissions, and ensures zero toxic residue.
Due to Azelaic Acid’s high melting point and poor water/oil solubility, crystal lattice structure dictates product elegance in topical emulsions. Our fluid-energy jet milling technology reduces crystal particle size down to D90 < 10 microns, eliminating gritty tactile feeling and accelerating skin bioavailability.
Addressing B2B procurement hurdles, solubility optimization, and cross-border commercial compliance across cosmetic, pharmaceutical, and specialty chemical markets.
Azelaic acid presents recrystallization challenges in aqueous phase gel formulations. Combining Azelaic Acid with hydrophilic solubilizers such as PPG-20 Methyl Glucose Ether (CAS 61849-72-7) or ethoxydiglycol enables robust crystal suspension and enhances skin penetration without requiring aggressive alcohol bases.
Demand for 10%, 15%, and 20% Azelaic Acid topical treatments is surging globally as first-line non-antibiotic therapies for acne vulgaris and rosacea. Global brand owners require reliable bulk raw materials with low heavy metal profiles, stable assay values, and full REACH, FDA DMF documentation.
Fluctuations in plant-based feedstock availability often destabilize market prices. JIMPOCHEM’s strategic multi-channel raw material sourcing combined with automated digital process controls guarantees multi-ton batch consistency, seamless continuous supply, and full batch traceability.
Designated Chemical Service Provider | Leading Fine Chemical Raw Material Production & One-Stop Global Solutions
JIMPOCHEM CO., LTD was established in 2010 and is headquartered in the Chemical Industry Park of Jinan City, Shandong Province. The company covers an area of over 500 acres and is a professional chemical raw material manufacturer that integrates research and development, production, sales, and technical services. Its core focus is on high-end fine chemicals and cosmetic raw materials. We have obtained multiple product-related certifications, including ISO quality system certification and environmental management system certification, and are committed to providing high-quality chemical products and one-stop procurement service solutions to global customers.
Our core team comprises experts with over 10 years of experience in the chemical industry. This enables us not only to provide professional products but also to offer solutions in product development, formula optimization, and supply chain management, meeting the personalized needs of diverse clients. We provide high-quality products and services, and our products are exported to over 200 countries and regions in Europe, America, Southeast Asia, the Middle East, and Oceania, serving more than 5,000 international companies. We have also established long-term strategic partnerships with many internationally renowned chemical companies, becoming a trusted "designated chemical service provider" for numerous clients.
Leveraging years of industry experience, we have established stable raw material procurement channels and partnered with top global chemical raw material suppliers, ensuring stable raw material quality and ample supply. Our modern production base employs an intelligent control system to automate and digitally manage the production process, balancing large-scale production with flexible customization needs. This allows for rapid response to large-volume orders and personalized product requests from our clients.
Adhering to the philosophy that "quality is the lifeline of an enterprise," the company has established a comprehensive quality control system. From raw material warehousing and inspection, real-time monitoring of the production process, to full-item inspection of finished products before shipment, every step adheres to strict quality standards to ensure that every batch of products delivered to customers meets relevant technical specifications. Simultaneously, a product traceability system has been established, allowing users to trace the source of raw materials, production process, testing data, and logistics information through batch numbers, achieving full traceability and supporting testing by authoritative third-party institutions.
In response to the global "dual-carbon" strategy, the company focuses on the research and development and production of green chemical products, adopting environmentally friendly production processes and optimizing wastewater, waste gas, and waste residue treatment systems to achieve compliant pollutant emissions and resource recycling. Many core products have obtained environmental certifications, helping downstream customers achieve green production transformation and jointly promoting the sustainable development of the chemical industry.
Our technical team provides one-on-one dedicated service tailored to the specific needs of clients across different industries and application scenarios. From product selection and formulation adjustments to application testing, we create customized chemical solutions to meet each client's actual requirements, helping them optimize production processes, reduce costs, and enhance product competitiveness.
Vision: To become a leading global provider of chemical solutions, leading technological innovation and green development in the industry. JIMPOCHEM adheres to the core values of "integrity, innovation, professionalism, and win-win cooperation," providing efficient services to create long-term value for every partner.
Delivering integrated "R&D - Production - Application - Service" chemical raw material matrices globally.
Cosmetics, skin treatment formulas, anti-acne serums, makeup, perfumes, facial cleansers, hand sanitizers, body wash, toothpaste, and high-performance detergents.
Production of Active Pharmaceutical Ingredients (API), dermatological excipients, advanced organic intermediates, solvents, catalysts, reactants, and medical anesthesia raw materials.
Specialty polymers, cosmetic packaging resins, automotive synthetic elastomers, tire manufacturing additives, industrial seals, and technical components.
Architectural coatings, decorative surface treatments, protective industrial coatings, eco-friendly printing inks, and specialty functional inks.
Natural acidulants, functional food preservatives, color stabilisers, and veterinary nutritional micro-additives ensuring shelf-life extension.
High-purity chemical solvents for semiconductor fabrication, printed circuit board (PCB) etchants, display material precursors, battery electrolyte additives (LITFSI).
Expert answers to common questions regarding Azelaic Acid anti-inflammatory applications, formulation guidance, quality verification, and bulk commercial orders.
Azelaic Acid exerts its anti-inflammatory effects primarily through three mechanisms: (1) suppressing the generation of reactive oxygen species (ROS) in neutrophils, (2) inhibiting nuclear factor kappa B (NF-κB) transcription to downregulate pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α, and (3) downregulating Kallikrein-5 protease expression to prevent the release of vasoactive inflammatory peptides (LL-37). This makes it highly effective for treating rosacea, acne vulgaris, and post-inflammatory hyperpigmentation.
JIMPOCHEM implements an automated digital control system throughout synthesis and purification. Every batch of Azelaic Acid undergoes rigorous testing using High-Performance Liquid Chromatography (HPLC) for assay purity (≥99.5% for pharma grade), Gas Chromatography (GC) for residual solvents, Differential Scanning Calorimetry (DSC) for melting point accuracy, and Malvern Laser Diffraction for uniform micronization (D90 < 10μm).
Because Azelaic Acid has low solubility in water and oil, we recommend pairing it with PPG-20 Methyl Glucose Ether (CAS 61849-72-7), Ethoxydiglycol, or Propanediol. These ingredients prevent recrystallization, enhance spreadability, and ensure a non-gritty texture in cosmetic creams, gels, and anti-acne suspensions.
Yes. We supply comprehensive technical compliance dossiers including Certificate of Analysis (COA), Safety Data Sheets (SDS / MSDS compliant with GHS), EU REACH registration documents, ISO 9001/14001 certificates, heavy metal residue reports, and microbial limit testing certifications to facilitate smooth international customs clearance.
Standard commercial MOQs start at 25 kg fiber drums with inner PE moisture-barrier bags. For customized micronization particle sizes or specialty OEM packaging, MOQs can be tailored. Standard lead times range from 7 to 14 working days depending on order volume and destination shipping routes.
Yes, JIMPOCHEM supports global cosmetic chemists and pharmaceutical researchers by providing free 50g–200g testing samples. Contact our technical sales engineering team to request sample dispatch along with technical data sheets.
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