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Tromethamine (also known as THAM, Tris Base, or Tris(hydroxymethyl)aminomethane, CAS 77-86-1) represents a critical organic compound featuring a primary amine and three hydroxyl groups. In contemporary global supply chains, THAM has evolved from a conventional biological buffer into an indispensable cornerstone for advanced biopharmaceutical manufacturing, molecular diagnostic kits, cell therapy media, personal care formulations, and specialized polymer synthesis.
The accelerating demand for high-purity THAM is predominantly propelled by breakthroughs in global mRNA vaccine technologies, monoclonal antibody (mAb) purification processes, and next-generation in-vitro diagnostics (IVD). Because THAM exhibits exceptional buffering capacity within the physiological pH range of 7.0 to 9.0, global procurement officers and formulation scientists actively seek reliable THAM suppliers capable of delivering multi-ton bulk volumes with ultra-low endotoxin levels, minimal heavy-metal impurities, and strict compliance with USP, EP, and ChP pharmacopeial standards.
Vital stabilizing buffer in lipid nanoparticle (LNP) delivery vectors, viral vector storage, and biological liquid formulations requiring stringent pH control.
Used as a mild neutralizer and skin-friendly emulsifier stabilizer in premium anti-aging formulations, replacing harsh alkanolamines.
Essential component in TAE/TBE buffer systems for DNA/RNA gel electrophoresis and high-sensitivity immunoassay reagent buffers.
To assist global procurement directors and quality assurance managers in evaluating potential supply partners, the chemical parameters below represent the benchmark standards maintained by high-grade chemical producers:
| Parameter / Chemical Property | Industrial Grade Standard | Pharma & Bio-Buffer Grade (Ultra-Pure) | Analytical Methodology |
|---|---|---|---|
| Chemical Name | Tris(hydroxymethyl)aminomethane / Tromethamine / THAM | IUPAC Nomenclature | |
| CAS Registry Number | 77-86-1 | Chemical Abstracts Service | |
| Purity / Assay (Dry Basis) | ≥ 99.0 % | ≥ 99.9 % | Acid-Base Titrimetry / HPLC |
| Appearance | White Crystalline Powder | Pure White Free-Flowing Crystals | Visual Inspection |
| Melting Point Range | 168.0 °C - 172.0 °C | 169.0 °C - 171.5 °C | Capillary Tube / DSC |
| pH (1M aqueous solution) | 10.0 - 11.5 | 10.3 - 10.9 | Potentiometric Glass Electrode |
| Bacterial Endotoxins | N/A | < 0.03 EU/mg | LAL Kinetic Chromogenic Test |
| Heavy Metals (as Pb) | ≤ 10 ppm | ≤ 1 ppm | ICP-MS Analysis |
| Absorbance (260nm / 280nm) | ≤ 0.05 | ≤ 0.01 | UV-Vis Spectrophotometry |
JIMPOCHEM CO., LTD was established in 2010 and is headquartered in the Chemical Industry Park of Jinan City, Shandong Province. The company covers an area of over 500 acres and is a professional chemical raw material manufacturer that integrates research and development, production, sales, and technical services. Its core focus is on high-end fine chemicals and cosmetic raw materials. We have obtained multiple product related certifications, including ISO quality system certification and environmental management system certification, and are committed to providing high-quality chemical products and one-stop procurement service solutions to global customers.
Our core team comprises experts with over 10 years of experience in the chemical industry. This enables us not only to provide professional products but also to offer solutions in product development, formula optimization, and supply chain management, meeting the personalized needs of diverse clients. We provide high-quality products and services, and our products are exported to over 200 countries and regions in Europe, America, Southeast Asia, the Middle East, and Oceania, serving more than 5,000 international companies. We have also established long-term strategic partnerships with many internationally renowned chemical companies, becoming a trusted "designated chemical service provider" for numerous clients.
Leveraging years of industry experience, we have established stable raw material procurement channels and partnered with top global chemical raw material suppliers, ensuring stable raw material quality and ample supply. Our modern production base employs an intelligent control system to automate and digitally manage the production process, balancing large-scale production with flexible customization needs. This allows for rapid response to large-volume orders and personalized product requests from our clients.
Adhering to the philosophy that "quality is the lifeline of an enterprise," the company has established a comprehensive quality control system. From raw material warehousing and inspection, real-time monitoring of the production process, to full-item inspection of finished products before shipment, every step adheres to strict quality standards to ensure that every batch of products delivered to customers meets relevant technical specifications. Simultaneously, a product traceability system has been established, allowing users to trace the source of raw materials, production process, testing data, and logistics information through batch numbers.
In response to the global "dual-carbon" strategy, the company focuses on the research and development and production of green chemical products, adopting environmentally friendly production processes and optimizing wastewater, waste gas, and waste residue treatment systems to achieve compliant pollutant emissions and resource recycling. Many core products have obtained environmental certifications, helping downstream customers achieve green production transformation and jointly promoting the sustainable development of the chemical industry.
We are committed to providing integrated "R&D - production - application - service" solutions for industries such as pharmaceuticals, daily chemicals, rubber and plastics, coatings, building materials, electronics, and new energy. Below is an overview of how THAM and our fine chemicals portfolio serve targeted sectors:
Production of active pharmaceutical ingredients (API), pharmaceutical excipients, intermediates, solvents, catalysts, reactants, and intravenous acidosis management therapies (Medical anesthesia & metabolic regulation).
Formulation of high-end skincare, makeup, perfumes, facial cleansers, hand sanitizers, body wash, toothpaste, and premium detergents requiring neutral pH buffers and mild emulsification.
Specialty chemicals for manufacturing semiconductors, printed circuit boards (PCBs), display materials, advanced battery systems, and lithium-ion electrolytes.
Serving industrial packaging, automobile components, tire manufacturing, architectural & decorative coatings, industrial printing inks, and specialty functional polymers.
Our technical team provides one-on-one dedicated service tailored to the specific needs of clients across different industries and application scenarios. From product selection and formulation adjustments to application testing, we create customized chemical solutions to meet each client's actual requirements, helping them optimize production processes, reduce costs, and enhance product competitiveness.
Our state-of-the-art facilities comprise dedicated synthesis workshops, ultra-pure crystallization chambers, multi-stage analytical testing labs, and standardized warehousing systems.
Designed for procurement engineers, QA specialists, and global supply chain directors seeking transparent technical verification regarding THAM (Tris Base CAS 77-86-1) procurement.
Select from our premium lineup of specialty surfactants, active ingredients, and industrial intermediates.
Vision: To become a leading global provider of chemical solutions, leading technological innovation and green development in the industry. JIMPOCHEM adheres to the core values of "integrity, innovation, professionalism, and win-win cooperation," providing efficient services to create long-term value for every partner. We look forward to working hand in hand with global partners to create a better future!
JIMPOCHEM
