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Methylbenzethonium Chloride (CAS No. 25155-18-4) represents a highly specialized synthetic quaternary ammonium compound (QAC) exhibiting potent antimicrobial, antiseptic, and surfactant properties. Chemically designated as Benzyldimethyl[2-[2-[m-tolyl(diisobutyl)phenoxy]ethoxy]ethyl]ammonium chloride or related isomer configurations, this cationic agent possesses a distinct amphiphilic structure comprising a lipophilic alkyl-aryl hydrophobic tail coupled to a hydrophilic quaternary ammonium headgroup.
Unlike conventional short-chain quaternary salts, Methylbenzethonium Chloride features a methylated aromatic core that imparts elevated lipophilicity and structural rigidity. This chemical topology enables superior cell membrane interaction against target pathogens, rendering it an essential raw material across pharmaceutical formulation, topical healthcare, veterinary biosecurity, and specialized personal care systems.
| Parameter Specification | Standard Technical Value | Testing Methodology / ISO standard |
|---|---|---|
| Chemical Name | Methylbenzethonium Chloride | IUPAC Identification |
| CAS Registry Number | 25155-18-4 / 1320-43-0 | Chemical Abstracts Service |
| Molecular Formula | C28H44CINO2 | Elemental Mass Calculation |
| Molecular Weight | 462.11 g/mol | High-Resolution Mass Spectrometry |
| Purity (Active Content) | ≥ 99.0% (Pharma/USP Grade) / ≥ 98.0% (Tech) | Potentiometric Titration / HPLC |
| Physical Appearance | White to off-white crystalline powder or viscous paste | Visual Inspection / Colorimetry |
| Melting Point Range | 159 °C – 163 °C | Capillary Melting Method (ISO 3146) |
| Solubility Profile | Soluble in water, ethanol, and acetone; insoluble in ether | Gravimetric Dissolution Analysis |
The cationic ammonium nitrogen atom of Methylbenzethonium Chloride electrostatically attracts negatively charged phospholipid headgroups on bacterial cell membranes. Upon adsorption, the long hydrophobic alkyl-phenoxy tail intercalates into the lipid bilayer, causing rapid structural disruption, potassium and amino acid leakage, loss of membrane potential, and ultimate cell lysis. It demonstrates broad-spectrum bactericidal action against Gram-positive bacteria (e.g., Staphylococcus aureus), Gram-negative pathogens (e.g., Pseudomonas aeruginosa), yeast, and enveloped viruses.
The manufacturing evolution of Methylbenzethonium Chloride has entered a new phase driven by green chemistry principles, continuous flow reaction design, and strict impurity elimination protocols:
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JIMPOCHEM CO., LTD was established in 2010 and is headquartered in the Chemical Industry Park of Jinan City, Shandong Province. The company covers an area of over 500 acres and is a professional chemical raw material manufacturer that integrates research and development, production, sales, and technical services. Its core focus is on high-end fine chemicals and cosmetic raw materials. We have obtained multiple product related certifications, including ISO quality system certification and environmental management system certification, and are committed to providing high-quality chemical products and one-stop procurement service solutions to global customers.
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Leveraging years of industry experience, we have established stable raw material procurement channels and partnered with top global chemical raw material suppliers, ensuring stable raw material quality and ample supply. Our modern production base employs an intelligent control system to automate and digitally manage the production process, balancing large-scale production with flexible customization needs. This allows for rapid response to large-volume orders and personalized product requests from our clients.
Adhering to the philosophy that "quality is the lifeline of an enterprise," the company has established a comprehensive quality control system. From raw material warehousing and inspection, real-time monitoring of the production process, to full-item inspection of finished products before shipment, every step adheres to strict quality standards to ensure that every batch of products delivered to customers meets relevant technical specifications. Simultaneously, a product traceability system has been established, allowing users to trace the source of raw materials, production process, testing data, and logistics information through batch numbers, achieving full traceability and supporting testing by authoritative third-party institutions.
In response to the global "dual-carbon" strategy, the company focuses on the research and development and production of green chemical products, adopting environmentally friendly production processes and optimizing wastewater, waste gas, and waste residue treatment systems to achieve compliant pollutant emissions and resource recycling. Many core products have obtained environmental certifications, helping downstream customers achieve green production transformation and jointly promoting the sustainable development of the chemical industry.
Delivering tailored chemical formulations, high-purity intermediates, and active ingredients across critical sectors.
Production of active pharmaceutical ingredients (API), pharmaceutical excipients, intermediates, solvents, catalysts, reactants, medical anesthesia formulations, and active topical antimicrobials like Methylbenzethonium Chloride for medical-grade disinfectants.
Cosmetics, makeup, perfume, facial cleansers, hand sanitizers, body wash, toothpaste, detergents, and skin-conditioning cationic preservatives that deliver persistent barrier protection against microbial flora.
Packaging materials, automobile components, tire manufacturing, industrial seals, performance additives, plasticizers, and functional antioxidant agents.
Architectural and decorative coatings, industrial high-performance protective coatings, printing inks, industrial specialty inks, and cationic dispersion aids.
High-purity food additives, natural and synthetic preservatives, specialized colorants, stabilizing emulsifiers, and nutritional feed supplement ingredients.
Semiconductor processing chemicals, printed circuit board (PCB) etchants, display materials, advanced battery chemistries, high-voltage electrolytes, and fluorinated thermal management liquids.
Our technical team provides one-on-one dedicated service tailored to the specific needs of clients across different industries and application scenarios. From product selection and formulation adjustments to application testing, we create customized chemical solutions to meet each client's actual requirements, helping them optimize production processes, reduce costs, and enhance product competitiveness.
Navigating global chemical compliance framework with certified technical documentation and regional support.
Procuring Methylbenzethonium Chloride and specialized fine chemicals requires stringent adherence to international regulatory frameworks. JIMPOCHEM supports global enterprise buyers by providing comprehensive compliance dossiers:
With exports extending to over 200 countries, our strategic proximity to major maritime ports (Qingdao, Tianjin, Shanghai) enables optimized multimodal transport solutions:
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While both are cationic quaternary ammonium salts, Methylbenzethonium Chloride features an additional methyl substituent on the aromatic ring of the phenoxy ethyl structure. This methyl modification alters its partition coefficient (LogP), increasing lipid membrane affinity and imparting slightly higher stability in specific surfactant matrixes and topical formulation environments.
Every batch shipped by JIMPOCHEM is accompanied by a full Certificate of Analysis (COA) detailing HPLC purity assay, melting point, loss on drying, heavy metals content, and residual solvent testing. Upon request, we also provide Safety Data Sheets (SDS) in accordance with GHS multi-language standards, REACH registration verification, BSE/TSE-free certificates, and ISO 9001/14001 compliance dossiers.
As a cationic compound, Methylbenzethonium Chloride can form insoluble electrical complexes or precipitates when directly combined with high concentrations of strongly anionic surfactants (such as Sodium Lauryl Sulfate, SLS). To maintain solution clarity and efficacy, formulation engineers recommend pairing it with non-ionic (e.g., Polysorbates, PPG glucose ethers) or amphoteric (e.g., Hydroxysultaines, Betaines) co-surfactants.
Our standard packaging for solid crystalline Methylbenzethonium Chloride is 25 kg fiber drums lined with double-layer PE moisture barrier bags. For trial batches and lab evaluations, sample packaging of 1 kg or 5 kg aluminum foil bags is available. We accommodate commercial orders ranging from multi-barrel LCL shipments to full container load (FCL) consignments.
Methylbenzethonium Chloride should be stored in tightly sealed original containers in a cool, dry, well-ventilated warehouse away from direct sunlight, heat sources, and strong oxidizing agents. Under optimal storage conditions (15 °C to 25 °C), the compound maintains a stable re-test shelf life of 24 to 36 months from the date of manufacture.
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Vision: To become a leading global provider of chemical solutions, leading technological innovation and green development in the industry. JIMPOCHEM adheres to the core values of "integrity, innovation, professionalism, and win-win cooperation," providing efficient services to create long-term value for every partner. We look forward to working hand in hand with global partners to create a better future!
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