Direct factory supply with full ISO batch traceability, rigorous HPLC/NMR validation, and global logistics readiness.
An exhaustive analysis of D-mannopyranose structural conformation, ring dynamics, equilibrium properties, and critical industrial specifications for global B2B procurement.
D-Mannopyranose (CAS 3458-28-4) represents the cyclic pyranose form of D-mannose, an aldohexose sugar C2-epimer of D-glucose. In aqueous solution, D-mannose undergoes dynamic ring-chain tautomerism, forming an equilibrium dominated by the six-membered pyranose ring. The thermodynamically stable conformers consist of α-D-mannopyranose (approximately 67%) and β-D-mannopyranose (approximately 33%), with trace amounts existing in open-chain aldehyde or furanose ring forms. The axial C2-hydroxyl orientation in D-mannopyranose gives rise to distinct physical characteristics, solubility profiles, and biochemical binding affinities unmatched by isomeric sugars.
For high-end pharmaceutical formulations and cell-culture feeds, batch-to-batch purity is paramount. Quality inspection relies on High-Performance Liquid Chromatography (HPLC) coupled with Refractive Index (RI) detection or mass spectrometry to confirm enantiomeric purity ≥ 99.5%. Key quality controls govern heavy metal limits (≤ 5 ppm), residue on ignition (≤ 0.1%), specific optical rotation ([α]D20 = +14.0° to +15.0° after mutarotation equilibrium), and strict endotoxin control (≤ 0.25 EU/mg for injectable or cell-grade variants).
SEO & Industry Insight: Commercial buyers frequently search for "D-Mannose Powder CAS 3458-28-4", "α-D-Mannopyranose bulk supplier", and "High-purity Mannopyranose for API synthesis". Ensuring exact stereochemical verification during procurement mitigates formulation failures in therapeutic glycobiology and targeted active pharmaceutical ingredient (API) manufacturing.
| Parameter / Hexose | D-Mannopyranose | D-Glucopyranose | D-Galactopyranose |
|---|---|---|---|
| CAS Number | 3458-28-4 | 50-99-7 | 59-23-4 |
| Chiral Difference | C-2 Epimer of D-Glucose | Standard Aldohexose Reference | C-4 Epimer of D-Glucose |
| C-2 Hydroxyl Orientation | Axial (α-anomer preferred) | Equatorial | Equatorial |
| Primary B2B Application | API / UTI Therapeutics / Glycoproteins | Excipient / Fermentation / Parenteral | Biopharmaceuticals / Cell Culture |
| Solubility in Water (20°C) | ~ 2,400 g/L (Extremely Soluble) | ~ 910 g/L | ~ 680 g/L |
| Mutarotation Specific Rotation | +14.0° → +14.6° | +112.2° → +52.7° | +150.7° → +80.2° |
Analyzing supply chain expansion, therapeutic adoption, and global procurement demand for specialized D-mannopyranose derivatives.
The global demand for D-mannopyranose has experienced exponential growth driven by the non-antibiotic management of Recurrent Urinary Tract Infections (rUTIs). D-Mannose specifically inhibits FimH adhesin protein mediated binding of uropathogenic Escherichia coli (UPEC) to uroepithelial receptors. This mechanism has positioned high-grade D-mannopyranose as a frontline ingredient in dietary supplements across North America and Western Europe, accelerating bulk demand at a CAGR of 7.4% (2024–2032).
In recombinant monoclonal antibody (mAb) production, precise N-glycosylation profiles determine therapeutic efficacy and immunogenicity. D-Mannopyranose is increasingly utilized as a critical cell culture medium additive to control high-mannose glycan structures (e.g., Man5, Man9). Leading biopharmaceutical enterprise buyers require ultra-pure, endotoxin-tested D-mannopyranose to optimize therapeutic antibody clearance rates and Fc-receptor binding affinity.
Beyond direct consumption, D-mannopyranose serves as a chiral building block for synthesizing complex oligosaccharides, nucleoside analogs, and specialty surfactant esters (such as mannoside alkyl ethers). The growth of green chemistry has boosted demand for renewable carbohydrate platforms, replacing petroleum-derived precursors in cosmetic active delivery vehicles and specialty polymers.
How advanced biotransformation technology, scale economies, and integrated supply networks deliver unmatched cost-quality value to global buyers.
Chinese chemical manufacturers, spearheaded by facilities like JIMPOCHEM CO., LTD in Jinan, Shandong, have transitioned from legacy acid-hydrolysis extraction to advanced multi-enzyme biocatalysis. Utilizing immobilized D-fructose 3-epimerase and D-glucose isomerase, Chinese facilities achieve conversion yields exceeding 92% with significantly reduced byproduct formation. This bio-enzymatic path dramatically cuts energy consumption and waste production.
Located in core agricultural and industrial belts, Chinese producers leverage direct access to high-purity D-glucose and D-fructose starch feedstocks. This cluster integration guarantees uninterrupted supply during global market fluctuations while minimizing raw material transit costs. Consequently, Western procurement managers can secure high-purity D-mannopyranose at cost savings of 25–40% compared to European or North American domestic synthesis.
Modern Chinese manufacturing facilities enforce comprehensive quality controls aligned with ISO 9001, ISO 14001, and cGMP guidelines. Automated DCS (Distributed Control Systems) manage crystallization parameters—controlling cooling curves to yield consistent particle size distributions (mesh 40–80 or micro-fine mesh 100). Every batch undergoes full-spectrum testing including HPLC, NMR, Heavy Metal ICP-MS, and microbiological pathogen screening prior to COA issuance.
Technical deployment across pharmaceuticals, personal care formulations, specialty bio-electronics, and animal health systems.
In oral solid dosage forms (tablets, capsules, and soluble sachets), D-mannopyranose serves both as a therapeutic active agent for urinary tract health and as a direct-compression binder-filler. Its low glycemic impact and rapid dissolution profile make it an ideal carrier for effervescent formulations. Formulators should maintain moisture-controlled environments (RH < 45%) during tableting due to the hygroscopic nature of fine-powder carbohydrate matrices.
Modern topical cosmetics utilize D-mannopyranose as a natural prebiotic conditioner. By selectively supporting beneficial skin microbiota (e.g., Staphylococcus epidermidis) while inhibiting pathogenic colonization, mannose-rich formulations reinforce skin stratum corneum integrity, suppress inflammation, and enhance transepidermal water retention. Recommended dosage range: 0.5% to 3.0% w/w in aqueous phase emulsions.
With global bans on prophylactic feed antibiotics, agricultural producers incorporate D-mannopyranose and mannan-oligosaccharides (MOS) into poultry and swine starter diets. D-Mannose binds pathogenic Salmonella and E. coli strains in the gastrointestinal lumen, promoting pathogen clearance through the feces without disturbing native gut flora or inducing antimicrobial resistance.
In life science research, high-purity α-D-mannopyranose is an essential substrate for studying lectin interactions (such as Concanavalin A affinity chromatography), cell surface glycoprotein receptor kinetics, and enzymatic carbohydrate pathways. Research institutions require analytical grade material (≥ 99.0% stereopurity) free of trace glucose or galactose contaminants.
A structured guide for corporate chemical buyers to secure reliable supply, verify quality parameters, and optimize procurement lead times.
Prior to issuing purchase orders, procurement managers must align vendor specifications with target application demands. Specify mesh size (e.g., 40–80 mesh for capsule filling vs fine micro-powder for liquid reconstitution) and set acceptable thresholds for moisture content (typically ≤ 0.5% loss on drying) and microbiological counts.
Ensure suppliers provide transparent batch traceability systems. Key vendors such as JIMPOCHEM facilitate batch number scanning to retrieve original raw material sources, reaction logbooks, QC testing charts, and shipping conditions, satisfying stringent FDA and EMA regulatory audits.
D-Mannopyranose is moisture-sensitive. Superior packaging utilizes multi-layer moisture barrier solutions: 25 kg fibre drums fitted with double food-grade polyethylene inner liners, heat-sealed with desiccants. Store under cool, dry conditions (≤ 25°C, RH ≤ 60%) to preserve free-flowing powder integrity and prevent caking over an extended 24-month shelf life.
Integrating R&D, green smart production, global sales, and technical service solutions for high-end fine chemicals and cosmetic raw materials.
Established in 2010 and headquartered in the Chemical Industry Park of Jinan City, Shandong Province, JIMPOCHEM CO., LTD covers an expansive industrial area of over 500 acres. Our core focus centers on high-end fine chemicals, carbohydrate derivatives, specialty fluorochemicals, and cosmetic active ingredients.
With full ISO quality system and environmental management certifications, our products are exported to over 200 countries and regions across Europe, North America, Southeast Asia, the Middle East, and Oceania, establishing strategic partnerships with over 5,000 international enterprises.
Answers to common technical, analytical, regulatory, and logistics queries from global B2B chemical buyers.
D-Mannose (CAS 3458-28-4) is the general chemical name for the aldohexose sugar. D-Mannopyranose specifically denotes the six-membered cyclic ether conformer adopted by D-mannose in solution and crystalline state. α-D-Mannopyranose refers to the specific anomer where the C-1 hydroxyl group is positioned axially relative to the ring plane. In commercial crystalline powder, α-D-mannopyranose is the dominant stereoisomer (>95%), which equilibrium mutarotates upon aqueous dissolution.
We provide three primary commercial grades:
1. Nutraceutical/Food Grade (≥ 98.5%): Ideal for dietary supplements, sachets, and animal health additives.
2. Pharmaceutical/API Grade (≥ 99.5%): Tested for strict heavy metals (≤ 5 ppm), low endotoxins (≤ 0.25 EU/mg), and compliance with USP/EP monographs.
3. Reagent/Cell Culture Grade (≥ 99.0%): Ultra-pure stereoisomeric material verified via high-resolution NMR and HPLC RI detection.
We control crystal growth during cooling crystallization, resulting in uniform particle size distributions (typically 40–80 mesh). Packaging is executed in HVAC air-conditioned cleanrooms (RH < 45%) using double polyethylene inner bags sealed inside moisture-resistant drums. Free-flowing properties are guaranteed throughout the 2-year shelf life under recommended storage conditions.
Every shipment includes a comprehensive document package: Batch Certificate of Analysis (COA), HPLC Chromatogram, Safety Data Sheet (SDS / MSDS compliant with GHS), Technical Data Sheet (TDS), Certificate of Origin (COO), ISO Quality Certifications, and Kosher/Halal certificates upon request.
Our standard Minimum Order Quantity (MOQ) for commercial production is 25 kg (1 drum). Free evaluation samples (100g – 500g) are dispatched via express air courier within 48 hours. Bulk ocean shipments (1 MT to 20 MT FCL) are dispatched from Qingdao or Shanghai ports within 7–14 business days from order confirmation.
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