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Azelaic Acid (1,7-heptanedicarboxylic acid, molecular formula C9H16O4) is a naturally occurring saturated dicarboxylic acid recognized as a gold-standard dermatological agent for addressing epidermal hyperpigmentation, post-inflammatory hyperpigmentation (PIH), melasma, and acne vulgaris. Unlike harsh depigmenting chemicals such as Hydroquinone, Azelaic Acid exhibits selective cytotoxic and cytostatic action target-focused exclusively on hyperactive or abnormal melanocytes, leaving normal epidermal pigmentation completely untouched.
Azelaic acid directly inhibits tyrosinase—the rate-limiting enzyme in melanogenesis—by blocking its active catalytic site. This halts the conversion of L-tyrosine into L-DOPA and subsequently DOPAquinone, effectively mitigating melanin synthesis at the biochemical source.
By reversibly inhibiting mitochondrial oxidoreductase enzymes and thioredoxin reductase, Azelaic Acid suppresses DNA synthesis and metabolic activity within abnormal, highly proliferative melano-cyto-pathological cells without inducing systemic cytotoxicity.
Demonstrating potent anti-inflammatory properties, Azelaic Acid decreases free radical generation by neutrophils. Free radicals are primary triggers for UV-induced skin darkening and post-inflammatory dermal damage.
| Active Ingredient | Primary Mechanism | Melanocyte Selectivity | Long-term Safety Profile | Global Regulatory Limits |
|---|---|---|---|---|
| Azelaic Acid (CAS 123-99-9) | Tyrosinase & Oxidoreductase Inhibition + ROS Neutralization | High (Only Hyperactive Cells) | Excellent (Non-cytotoxic, No Ochronosis Risk) | OTC Cosmetic up to 10%; Rx 15-20% (NMPA, FDA, EU) |
| Hydroquinone | Substrate Competition & Melanocyte Destruction | Low (Destroys Normal Melanocytes) | Poor (High risk of Exogenous Ochronosis & rebound) | Banned in OTC cosmetics in EU, US, China |
| Kojic Acid | Copper Chelation at Tyrosinase Active Site | Moderate | Moderate (High sensitization & oxidation risk) | Restricted to 1.0% in EU cosmetic formulations |
| Alpha-Arbutin | Reversible Tyrosinase Activity Inhibition | Moderate | Good (Risk of Hydroquinone release under heat) | Max 2.0% in face products (EU SCCS) |
| Tranexamic Acid | Plasminogen/Plasmin Pathway & Prostaglandin Blockade | Indirect (Vascular & Inflammatory Pathway) | Excellent | 2.0% - 3.0% standard OTC dosage |
JIMPOCHEM CO., LTD operates a state-of-the-art chemical manufacturing ecosystem spanned across 500+ acres in the Jinan Chemical Industry Park, Shandong Province. Driven by intelligent automation, digital continuous-flow synthesis, and rigorous green chemistry standards, we provide enterprise partners worldwide with unparalleled purity, batch consistency, and cost efficiency.
Our Azelaic Acid production utilizes advanced green catalytic oxidative cleavage of oleic acid feedstocks. Controlled catalytic reaction loops ensure low side-product generation, yielding raw powder with an active chemical purity exceeding 99.5% with zero toxic solvent residue.
Addressing the common formulation challenge of raw Azelaic Acid crystallization and grittiness, our factory offers customized particle micronization (D50 < 5µm, D90 < 15µm). Micronized Azelaic Acid delivers smooth texture, superior cream suspension, and accelerated transdermal absorption.
Every single batch undergoes continuous digital monitoring via automated inline sensors. From incoming oleic raw materials to final packaging, full chromatographic spectra (HPLC, GC-MS) and heavy metal analytical records are archived in our LIMS for complete 10-year traceability.
Integrating Azelaic Acid into stable cosmetic or pharmaceutical vehicles presents solubilization challenges due to its limited water solubility (approx. 2.4 g/L at 20°C) and high melting point (106.5°C). JIMPOCHEM offers specialized formulation guidance and derivative raw materials to help brands bypass recrystallization and sensory roughness.
Targeting hyperpigmentation, uneven skin tone, and daily brightening for sensitive and rosacea-prone skin types.
Prescription-strength creams (15-20%) formulated for clinical treatment of severe melasma, acne vulgaris, and papulopustular rosacea.
Acts as a potent 5-alpha-reductase inhibitor in anti-hair-loss tonics to prevent dihydrotestosterone (DHT)-induced alopecia.
Precursor raw material used in engineering high-performance polyamides, plasticizers, and specialty lubricity agents.
Streamlining bulk chemical purchasing for cosmetic brand owners, contract manufacturers (CDMO/CMO), and pharmaceutical formulators with stringent quality assurance and global logistics networks.
| INCI Name: | Azelaic Acid |
| CAS Number: | 123-99-9 |
| EINECS No: | 204-669-1 |
| Appearance: | White to off-white crystalline powder |
| Assay (HPLC): | ≥ 99.5% Active Acid |
| Melting Range: | 105.0 °C — 109.0 °C |
| Heavy Metals (as Pb): | ≤ 10 ppm |
| Loss on Drying: | ≤ 0.5% |
JIMPOCHEM ensures seamless market access across North America, Europe, Asia-Pacific, and Latin America through standard regulatory documentation packages:
The future of skin brightening chemistry lies in enhancing bio-availability, reducing skin irritation profiles, and advancing sustainable bio-fermentation synthesis. JIMPOCHEM R&D labs are pioneering next-generation delivery vehicles and bio-based derivatives.
Novel lipid nanocarriers (SLNs) encapsulate Azelaic Acid within phospholipid bilayers, allowing sustained release into deeper epidermal layers while eliminating surface skin sting and dryness associated with high acid concentrations.
Moving toward zero-carbon chemical manufacturing, our research pipeline tests engineered yeast strains to ferment plant oils directly into Azelaic Acid, reducing energy footprint by 40% and offering 100% bio-based carbon index.
Developing novel hybrid molecules combining Azelaic Acid with Ferulic Acid and Ascorbic Acid to create single-molecule multi-target actives capable of simultaneously brightening, soothing, and repairing dermal matrices.
Expert answers to critical technical, chemical formulation, and bulk ordering questions regarding Azelaic Acid.
In addition to skin brightening active ingredients, JIMPOCHEM produces premium raw materials for Daily Chemicals, Organic Intermediates, Healthcare, and Fluorine Chemistry.
PPG-20 Methyl Glucose Ether, Lauryl Hydroxysultaine, Bemotrizinol UV Filters, Zinc Pyrithione anti-dandruff agents.
Tetradecane, Diallyl Trisulfide, ε-Polylysine preservatives, D-Mannose, N,N'-Bis(1-methylpropyl)-1,4-phenylenediamine.
Tris Base biological buffers, Glutathione API, Sodium Caprylate, O-Phthalaldehyde clinical disinfectants.
Lithium Bis(trifluoromethanesulfonyl)imide (LITFSI), Methyl Perfluoroisobutyl Ether (HFE-7100), Ethyl Nonafluorobutyl Ether.
Complete supply catalog of trusted raw materials available for immediate bulk dispatch and sample evaluation.
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