Explore our top-tier cosmetic, pharmaceutical, and specialty chemical portfolio manufactured to ISO & REACH standards.
Understanding the molecular mechanisms, pKa balances, and dual-action pathways for acne vulgaris, rosacea, and post-inflammatory hyperpigmentation (PIH).
A saturated dicarboxylic acid ($C_9H_{16}O_4$) naturally derived from grains. It functions as a reversible inhibitor of tyrosinase and oxidoreductase enzymes, selectively targeting hyperactive abnormal melanocytes without affecting normal pigmentation. Its anti-inflammatory properties inhibit 5-alpha-reductase, neutralizing reactive oxygen species (ROS).
An aromatic Alpha Hydroxy Acid (AHA) derived from bitter almonds ($C_8H_8O_3$). Featuring a larger molecular weight ($152.15\text{ g/mol}$) compared to Glycolic Acid ($76.05\text{ g/mol}$), it penetrates the stratum corneum slowly and uniformly, drastically reducing micro-stinging and erythema—ideal for sensitive & fitzpatrick IV-VI skin types.
While Mandelic Acid solubilizes lipophilic follicular sebum deposits to unclog pores, Azelaic Acid normalizes follicular hyperkeratinization by lowering synthesis of filaggrin. Combining both actives offers a dual-action approach: epidermal desquamation paired with targeted antimicrobial suppression of Cutibacterium acnes.
Azelaic Acid exhibits poor aqueous solubility ($2.4\text{ g/L}$ at $20^\circ\text{C}$). Achieving stable cosmetic suspensions or micro-emulsions requires advanced solubilizers such as PPG-20 Methyl Glucose Ether or ethoxydiglycol, maintained within a strict pH window of $3.8 - 4.5$ to ensure active bioavailability.
| Physicochemical Parameter | Azelaic Acid (Dicarboxylic Acid) | Mandelic Acid (Lipophilic AHA) | Synergistic Combination Benefit |
|---|---|---|---|
| CAS Registry Number | 123-99-9 | 90-64-2 | Dual-active listing for regulatory compliance |
| Molecular Weight | 188.22 g/mol | 152.15 g/mol | Balanced epidermal penetration speed |
| pKa Value | pKa1 = 4.53, pKa2 = 5.33 | pKa = 3.41 | Stable buffering between pH 3.8 and 4.2 |
| Solubility Profile | Slightly soluble in water, soluble in ethanol/glycols | Soluble in water, ethanol, and polar solvents | Enhanced clear-gel and serum stability |
| Primary Target Action | Tyrosinase inhibition, anti-inflammatory ROS reduction | Corneum desquamation, sebum breakdown | Comprehensive acne & melasma treatment |
| Recommended B2B Concentration | 5.0% – 20.0% (OTC to Prescription) | 2.0% – 15.0% (Cosmeceutical formulations) | Custom ratios tailored to clinical sensitivity profiles |
Delivering high-purity chemical actives globally from our integrated 500+ acre industrial base in Jinan, Shandong Province.
Headquartered in the Jinan Chemical Industry Park, JIMPOCHEM CO., LTD operates across more than 500 acres of state-of-the-art chemical manufacturing infrastructure. Founded in 2010, our facility incorporates fully automated closed-loop synthesis lines that minimize batch variations.
Our dynamic process control systems track reaction kinetics, oxidation, and crystallization steps digitally. This ensures that raw materials such as Azelaic Acid, Mandelic Acid, and cosmetic esters consistently achieve assays exceeding 99.5% HPLC purity with controlled particle size distribution (PSD).
By securing direct, long-term procurement agreements for key petrochemical and bio-based precursors, JIMPOCHEM mitigates global supply chain volatility. Our direct-from-factory pricing protects global partners against price swings in fine chemical markets.
Meeting strict international cosmetic and chemical compliance standards for seamless export into North America, the EU, APAC, and LATAM markets.
Our quality and environmental management systems strictly adhere to ISO international standards. Every synthesis batch undergoes end-to-end verification, from raw material arrival to final product packaging.
We supply complete compliance packages for formulators and brand owners, including Certificate of Analysis (COA), Safety Data Sheets (SDS compliant with GHS/CLP), Heavy Metal Assays, Microchemical Impurity Profiles, and BSE/TSE statements.
Our raw materials are evaluated to align with EU CosIng listings and US FDA cosmetic ingredient parameters. Heavy metals ($\text{Pb, As, Hg, Cd}$) are maintained below $10\text{ ppm}$, matching demanding clean beauty standards globally.
We support various packaging configurations—from $25\text{ kg}$ fiber drums for standard factory production to customized sea/air freight pallets with climate-controlled tracking for sensitive cosmetic active deliveries.
Key drivers behind the accelerating market adoption of Azelaic Acid and Mandelic Acid formulations globally.
Consumers are moving away from abrasive mechanical scrubs and aggressive high-percentage Glycolic peels. Mandelic Acid's slow skin-penetration kinetics position it as the leading choice for daily sensitive-skin renewal formulations.
Combining Azelaic Acid (anti-redness & melanocyte regulation) with Mandelic Acid (pore decongestion) provides formulators with an all-in-one serum strategy addressing post-acne scarring, melasma, and irregular texture simultaneously.
Driven by the "skinification of hair and body", active acids are expanding beyond facial serums into anti-keratosis pilaris body lotions, scalp clarifying cleansers, and underarm brightening deodorants.
How R&D teams integrate Azelaic Acid and Mandelic Acid across various end-use cosmetic and dermatological formats.
Formulation Framework: 10% Azelaic Acid + 5% Mandelic Acid water-in-oil emulsion.
Target: Reduces papules, pustules, and comedones while regulating excess sebum production without stripping skin moisture.
Formulation Framework: 15% Azelaic Acid combined with soothing anti-inflammatory agents like Sodium L-pyroglutamate.
Target: Calms persistent facial erythema and vascular reactivity associated with erythematotelangiectatic rosacea.
Formulation Framework: 8% Mandelic Acid + 2% Ascorbyl Glucoside (AA2G).
Target: Gently exfoliates hyperpigmented surface keratinocytes while down-regulating melanosome transfer, brightening post-sun discoloration.
Formulation Framework: 3% Mandelic Acid paired with Zinc Pyrithione.
Target: Cleanses follicular build-up on the scalp, balances microflora, and alleviates seborrheic dermatitis flaking.
A trusted global supplier of fine chemicals, pharmaceutical intermediates, and cosmetic actives.
JIMPOCHEM CO., LTD was established in 2010 and is headquartered in the Chemical Industry Park of Jinan City, Shandong Province. The company covers an area of over 500 acres and is a professional chemical raw material manufacturer that integrates research and development, production, sales, and technical services. Its core focus is on high-end fine chemicals and cosmetic raw materials. We have obtained multiple product-related certifications, including ISO quality system certification and environmental management system certification, and are committed to providing high-quality chemical products and one-stop procurement service solutions to global customers.
Our core team comprises experts with over 10 years of experience in the chemical industry. This enables us not only to provide professional products but also to offer solutions in product development, formula optimization, and supply chain management, meeting the personalized needs of diverse clients. We provide high-quality products and services, and our products are exported to over 200 countries and regions in Europe, America, Southeast Asia, the Middle East, and Oceania, serving more than 5,000 international companies. We have also established long-term strategic partnerships with many internationally renowned chemical companies, becoming a trusted "designated chemical service provider" for numerous clients.
Providing integrated "R&D - Production - Application - Service" solutions across six major chemical sectors.
Cosmetics, active skin creams, perfumes, facial cleansers, hand sanitizers, body wash, hair care formulations, toothpaste, and specialty surfactants.
Production of active pharmaceutical ingredients (API), pharmaceutical excipients, synthesis intermediates, solvents, catalysts, and medical anesthesia agents.
High-performance polymer packaging materials, automotive synthetic components, tire manufacturing additives, seals, and specialized industrial components.
Architectural and decorative coatings, industrial anti-corrosion protective paints, high-precision printing inks, and specialty industrial solvents.
Safe food preservation agents, functional nutritional additives, legal food colorants, and specialized livestock feed fortifiers.
High-purity chemical solvents for semiconductor fabrication, printed circuit boards (PCBs), display panel materials, battery electrolytes, and LITFSI salts.
Detailed technical and commercial answers for cosmetic formulators, procurement managers, and regulatory directors.
Browse our extended inventory of active cosmetic ingredients, organic intermediates, and specialized industrial compounds.
Connect with our sales engineering team for technical specifications, COA requests, and customized OEM supply solutions.
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