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Comprehensive analysis of 4-Chloro-3,5-dimethylphenol (CAS 88-04-0) chemistry, spectrum efficacy, and formulation stability.
Chloroxylenol, chemically designated as 4-chloro-3,5-dimethylphenol and structurally classified under CAS number 88-04-0 (also widely referred to as PCMX), serves as a foundational broad-spectrum antimicrobial agent across global pharmaceutical, cosmetic, and industrial sanitation sectors. Featuring a substituted phenolic ring structure with hydrophobic methyl groups and an electronegative chlorine substituent, Chloroxylenol exerts exceptional bactericidal, fungicidal, and virucidal properties through targeted microbial cell membrane lysis and intracellular enzyme denaturation.
In modern chemical engineering, China has established itself as the world's primary synthesis center for Chloroxylenol. Driven by integrated chemical industrial complexes, abundant raw material feedstocks (such as 3,5-xylenol and continuous chlorination reagents), and automated multi-stage purification processes, top-tier Chinese manufacturers deliver EP, USP, and BP compliance grade Chloroxylenol with purity levels reaching up to 99.5% minimum. This technical overview provides an authoritative insight into purchasing, formulating, and scaling applications using high-grade Chloroxylenol sourced from China's leading chemical facilities.
| Chemical Property / Parameter | Technical Specification (JIMPOCHEM Standard) | Analytical Method Reference |
|---|---|---|
| Chemical Name | 4-Chloro-3,5-dimethylphenol (Chloroxylenol / PCMX) | IUPAC Nomenclature |
| CAS Registry Number | 88-04-0 | CAS Standard Index |
| Assay / Purity (Dry Basis) | 99.0% – 99.8% Min | HPLC / GC Analysis |
| Appearance | White to Off-White Crystalline Powder / Granules | Visual Inspection |
| Melting Point Range | 114.0 °C – 116.0 °C | Capillary Tube Method |
| Water Solubility (20°C) | Approx. 0.03% w/v (Highly Soluble in Alcohol, Ether, Alkaline Solutions) | Gravimetric Solubility |
| Free Phenol Content | < 0.1% Max | Gas Chromatography |
| Heavy Metal Residues (as Pb) | ≤ 10 ppm | ICP-MS Spectrometry |
Analyzing shifting supply networks, regulatory compliance (REACH/EPA), and corporate purchasing strategies.
Post-pandemic healthcare standards have permanently elevated global consumption of surgical scrubs, skin antiseptics, and hospital-grade surface disinfectants, driving steady 6.8% CAGR demand growth for medical-grade Chloroxylenol.
Global procurement teams prioritize vendors offering comprehensive regulatory dossiers, including REACH registration in Europe, EPA registration compliance in the US, and low residual chloroform content to satisfy eco-label regulations.
Formulators in personal care (anti-dandruff shampoos, antibacterial hand washes) are transitioning away from triclosan and parabens toward Chloroxylenol due to its proven safety profile, lower bioaccumulation, and non-irritating nature at therapeutic levels.
How JIMPOCHEM's automated production infrastructure delivers scale, batch consistency, and cost optimization.
Located in the Chemical Industry Park of Jinan City, Shandong Province, JIMPOCHEM CO., LTD operates a state-of-the-art facility spanning over 500 acres. Integrating R&D, chemical synthesis, and technical services, JIMPOCHEM embodies the "China Factory 4.0" initiative through digitalized continuous-flow chlorination technology, real-time stoichometric control, and closed-loop environmental purification systems.
The synthetic production of Chloroxylenol requires precision control over the chlorination of 3,5-dimethylphenol to prevent over-chlorinated impurities such as 2,4-dichloro-3,5-dimethylphenol. By implementing DCS (Distributed Control Systems) automated reaction monitoring, JIMPOCHEM achieves exceptional regioselectivity, eliminating toxic off-target isomers while minimizing energy consumption and carbon emissions in alignment with China's dual-carbon sustainability targets.
From healthcare antiseptics to industrial biocide systems: Tailored dosage and dispersion methodologies.
Utilized in surgical hand scrubs (concentration 0.5%–2.0% w/v) and skin prep antiseptics. Dissolved in isopropyl alcohol or solubilized using castor oil soap (Pine Oil formulations) for rapid microbicidal action against Staphylococcus aureus and Pseudomonas aeruginosa.
Formulated into iconic brown liquid household disinfectants (4.8% w/v Chloroxylenol active). Upon dilution in water, it forms a characteristic milk-white emulsion (phenolic blooming effect), offering robust surface cleaning and laundry sanitization.
Acts as an effective anti-fungal agent controlling Malassezia globosa in anti-dandruff shampoos (0.1%–0.5% dosage). Often combined synergistically with Zinc Pyrithione for broad-spectrum scalp microflora regulation.
Protects metalworking fluids, leather finishing agents, paper pulp suspensions, and architectural coatings from microbial degradation. Resists bio-fouling in high-humidity industrial environments.
Integrating chemical R&D, automated manufacturing, stringent quality assurance, and bespoke B2B customer support.
Founded in 2010, JIMPOCHEM CO., LTD has evolved into an international powerhouse in high-end fine chemicals and specialty cosmetic ingredients. Operating over 500 acres of advanced facility space in Jinan City, our core technical team brings over 16 years of direct industry experience. We do not simply supply chemical compounds; we deliver end-to-end solutions spanning synthesis customization, formula optimization, scale-up production, and international regulatory support.
Adhering to the core philosophy that "Quality is the lifeline of an enterprise," JIMPOCHEM maintains rigorous batch-level quality control. From raw material spectrum validation to finished product HPLC verification, every batch of Chloroxylenol is backed by a full Certificate of Analysis (CoA) and complete digital traceability. Our eco-friendly production processes ensure zero non-compliant emissions, enabling our global clients to fulfill their sustainability and ESG targets seamlessly.
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