Explore our premium-grade chemical active ingredients, specialty intermediates, and dermatological formulations supplied directly from our Shandong manufacturing complex.
In global clinical dermatology and therapeutic skincare, Azelaic Acid 20 Percent Cream stands out as a versatile, scientifically validated topical intervention. As a naturally occurring saturated 9-carbon dicarboxylic acid—synthesized chemically via high-efficiency catalytic oxidation pathways—Azelaic Acid possesses unique pharmacological profiles: it acts simultaneously as a competitive inhibitor of tyrosinase, a potent anti-comedogenic agent, an anti-inflammatory molecule regulating follicular keratinization, and a targeted antimicrobial against Cutibacterium acnes and Staphylococcus epidermidis.
As global demand escalates for high-potency, non-retinoid, non-antibiotic treatments for mild-to-moderate Acne Vulgaris, Papulopustular Rosacea, and Post-Inflammatory Hyperpigmentation (PIH), global dermatological brands and pharmaceutical distributors face escalating supply chain complexity. Choosing a verified China Azelaic Acid 20 Percent Cream Manufacturer & Supplier offers significant competitive advantages: access to vertically integrated API production, advanced micro-milling particle dispersion technology, robust regulatory dossier backing (DMF/REACH/GMP), and cost structures optimized for scale.
Resolving solubility challenges, optimizing epidermal bioavailability, and mastering phase stability in high-concentration dicarboxylic acid emulsions.
Raw Azelaic Acid exhibits poor water solubility (<2.4 g/L at 20°C) and a naturally gritty crystal structure. JIMPOCHEM applies high-energy jet-milling micronization, achieving a strictly controlled Particle Size Distribution with D90 < 10 µm. This guarantees a velvety, non-gritty skin-feel while maximizing skin surface area for rapid epidermal absorption.
Therapeutic stability of 20% Azelaic Acid requires precise pH targeting between pH 4.0 and 4.8. At this buffer range, the ratio of un-ionized to ionized dicarboxylic acid is optimized to penetrate the lipophilic stratum corneum without inducing erythema or cutaneous burning commonly associated with unbuffered formulations.
Our formulation utilizes a specialized oil-in-water (O/W) liquid crystal emulsion system incorporating high-grade lipophilic carriers such as Isopropyl Myristate (CAS 110-27-0) and polyol solubilizers. This prevents polymorphic crystal growth over extended 36-month shelf-life storage, ensuring zero phase separation.
| Specification Parameter | Dermatological Grade Target | Testing Methodology / Standard | Analytical Result |
|---|---|---|---|
| Active Azelaic Acid Assay | 19.0% – 21.0% w/w | HPLC-UV Quantitative Analysis | 20.15% (Compliant) |
| Particle Size Distribution (PSD) | D90 < 10.0 µm; D50 < 4.5 µm | Laser Diffraction (Malvern Mastersizer) | D90 = 7.8 µm (Micronized) |
| Formulation pH Value | 4.20 – 4.70 at 25°C | Potentiometric pH Direct Measurement | 4.45 |
| Viscosity Profile | 45,000 – 75,000 cP | Brookfield RVT, Spindle 6, 10 rpm | 58,500 cP |
| Heavy Metal Impurities | Pb < 5 ppm, As < 1 ppm, Cd < 1 ppm | ICP-MS Heavy Metal Screening | Conforms to EP / USP Specs |
| Microbiological Contamination | Total Aerobic < 100 CFU/g; Absence of pathogens | Microbial Limit Testing (USP <61/62>) | Zero Detection (Sterile Grade) |
Operating from our 500+ acre chemical production hub in Jinan City, Shandong Province, JIMPOCHEM delivers unmatched industrial scale and technological leadership.
Our continuous catalytic oxidation loop utilizes Distributed Control System (DCS) digital monitoring. By precisely balancing pressure, reactant concentrations, and crystallization temperature, we guarantee raw material purity exceeding 99.5% for active Azelaic Acid, minimizing mono-carboxylic and long-chain residual impurities.
In accordance with global dual-carbon mandates, our facility operates closed-loop wastewater purification and catalytic gas scrubbers. Our bio-based Azelaic Acid precursor routes reduce carbon footprint by up to 35% compared to traditional ozonolysis of oleic acid.
With localized warehouses near Qingdao Port and Shanghai Port, JIMPOCHEM guarantees reliable export logistics to over 200 countries and regions. Integrated cold-chain and temperature-controlled maritime containers protect cream formulations during transit across climate zones.
Pioneering next-generation delivery systems for enhanced skin bioavailability, reduced tingling sensations, and bio-fermentative synthesis.
Our R&D pipeline focuses on lipid nanoparticle (LNP) encapsulation of 20% Azelaic Acid. By enclosing active molecules in phospholipid bilayers, sustained release into the pilosebaceous unit is achieved, mitigating initial sting reactions while doubling cutaneous residence time.
Formulation innovations combine Azelaic Acid 20% with complementary actives: Niacinamide (barrier repair), Glycolic Acid (CAS 79-14-1) (stratum corneum desquamation), and stable Vitamin C derivatives like AA2G (CAS 129499-78-1) for clinical hyperpigmentation management.
In partnership with university chemical laboratories, JIMPOCHEM is pioneering synthetic biology processes using modified yeast strains to ferment plant-based fatty acids into 100% bio-derived Azelaic Acid, reducing reliance on traditional chemical oxidation routes.
Flexible raw material supply and turnkey finished product manufacturing for international pharmaceutical, cosmeceutical, and retail brand partners.
We supply high-purity API active powders and bulk emulsion bases compliant with European Pharmacopoeia (EP) and United States Pharmacopeia (USP) monographs for prescription acne and rosacea treatments.
Custom OEM/ODM formulation services allow global skincare brands to launch 20% or 15% Azelaic Acid creams, gels, and serum-creams under private labels with custom fragrance-free, vegan, or sensitive-skin credentials.
To preserve cream stability and prevent air-induced oxidation, we offer filling services into multi-layer aluminum tubes, airless pump bottles, and medical-grade packaging materials under class 100,000 cleanrooms.
Adhering strictly to global quality frameworks to ensure seamless market entry across Europe, the Americas, Asia-Pacific, and the Middle East.
At JIMPOCHEM, our operating philosophy centers on the core value that "quality is the lifeline of an enterprise." From raw material intake to final product delivery, every step is stringently monitored within our ISO 9001 and ISO 14001 certified management systems.
We provide full dossier support for international product registration, including Certificate of Analysis (COA), Safety Data Sheets (MSDS), Technical Data Sheets (TDS), Method of Analysis (MOA), Stability Study Data (ICH Guidelines), and EU REACH registration compliance.
Every commercial batch is linked to a QR-coded digital traceability key, allowing downstream procurement managers to trace raw material origins, reactor parameters, analytical HPLC chromatograms, and logistics chain history instantly.
In addition to our in-house state-of-the-art testing laboratory, we routinely partner with accredited independent third-party laboratories (SGS, Intertek, Eurofins) for external assay verification and impurity profiling.
Streamlined procurement workflows for chemical buyers, cosmetics contract manufacturers, and pharmaceutical importers.
Raw Material Powder: 25kg fiber drums with dual PE inner liners.
Finished Cream Formulations: Bulk 50kg/200kg drums for filling, or retail-ready 15g/30g/50g branded tubes with custom outer cartons.
API Active Powder: From 25 kg sample drums.
OEM/ODM Finished Cream: 3,000 units for standardized formulations; 10,000 units for fully customized formulations and custom secondary packaging.
We provide rapid sample dispatch (200g – 1kg sample batches) within 48 hours for laboratory batch testing and compatibility trials, backed by technical support from our formula engineers.
Expert insights addressing critical technical, formulation, stability, and regulatory queries regarding 20% Azelaic Acid Cream procurement.
Established in 2010 | 500+ Acres Manufacturing Base | Headquartered in Jinan Chemical Industry Park, Shandong Province
JIMPOCHEM CO., LTD was established in 2010 and is headquartered in the Chemical Industry Park of Jinan City, Shandong Province. Spanning an operational area of over 500 acres, our enterprise integrates advanced R&D, continuous industrial manufacturing, global export sales, and deep technical application support. We specialize in high-end fine chemicals, cosmetic active raw materials, and dermatological formulations.
Our core engineering team comprises industry veterans with over 16 years of chemical synthesis and pharmaceutical formulation experience. Holding ISO 9001 quality management and ISO 14001 environmental management system certifications, JIMPOCHEM is a trusted, designated service provider for over 5,000 international companies across 200+ countries.
Corporate Exterior & Headquarters
16+ Years Industry Experience
Advanced R&D Laboratory Facilities
Explore our secondary catalog of specialized daily chemical ingredients, pharmaceutical excipients, and fluorinated compounds.
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