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Ascorbyl Tetraisopalmitate, chemically designated as Tetrahexyldecyl Ascorbate (CAS No. 183476-82-6 / 183476-82-6), represents the pinnacle of modern cosmetic vitamin derivative synthesis. Unlike standard L-ascorbic acid, which suffers from extreme oxidative instablity, rapid discoloration in aqueous media, and poor cutaneous penetration due to its hydrophilic nature, Ascorbyl Tetraisopalmitate is a fully esterified, tetra-lipophilic derivative of L-ascorbic acid coupled with branched-chain isopalmitic acid molecules.
The core ascorbic acid ring is completely shielded by four bulky isopalmitate ester chains. This steric hindrance prevents premature electron donation and atmospheric oxidation, allowing formulas to withstand thermal processing up to 80°C without darkening or losing potency.
Due to its ultra-high lipophilicity (Log P > 10), Ascorbyl Tetraisopalmitate seamlessly traverses the hydrophobic stratum corneum lipid bilayer. Comparative cellular uptake assays show penetration rates up to 5 times higher than hydrophilic L-ascorbic acid.
Once inside viable epidermal and dermal cells, intracellular esterases selectively cleave the four ester bonds, releasing pure free L-ascorbic acid directly inside keratinocytes and fibroblasts to stimulate collagen synthesis and neutralize ROS.
As a leading China Ascorbyl Tetraisopalmitate supplier, JIMPOCHEM utilizes advanced multi-stage esterification and high-vacuum molecular distillation technology. The synthesis protocol requires precise stoichiometric control to achieve 100% tetra-esterification while eliminating mono-, di-, and tri-substituted side products that compromise long-term shelf life.
| Synthesis Metric / Step | Generation 1 (Legacy Acid Catalyst) | Generation 2 (Conventional Base Catalysis) | Generation 3 (JIMPOCHEM Advanced Catalytic Process) |
|---|---|---|---|
| Assay Purity (HPLC) | 93.5% - 95.0% | 95.5% - 97.5% | ≥ 98.0% (Ultra-High Purity Grade) |
| Free Isopalmitic Acid Content | < 3.0% | < 1.5% | < 0.5% (Minimizes Formula Cloudiness) |
| Color (Hazenn / APHA) | ≤ 150 (Yellowish tint) | ≤ 80 (Light Yellow) | ≤ 30 (Water-Clear to Light Straw) |
| Heavy Metal Limits (Pb, As, Hg, Cd) | < 20 ppm cumulative | < 10 ppm cumulative | < 2 ppm Ultra-Clean ICP-MS Verified |
| Process Sustainability | High solvent waste | Moderate recovery | Closed-loop solvent recycling, zero toxic emissions |
Our facility utilizes short-path molecular distillation operating under high vacuum (< 0.01 mbar). This thermal-safe purification step removes volatile odor components and residual unreacted substrates without thermally degrading the sensitive ester bonds.
Every commercial batch undergoes comprehensive characterization using High-Performance Liquid Chromatography (HPLC), Gas Chromatography (GC) for residual solvents, and Fourier-Transform Infrared Spectroscopy (FTIR) structural confirmation.
Ascorbyl Tetraisopalmitate’s oil solubility makes it extremely versatile across luxury skincare formats. It resolves classical formulation headaches such as low pH requirements, oxidation-induced phase separation, and metallic skin feel. Below are detailed engineering parameters for localized application scenarios:
Dosage: 1.0% - 10.0%
In anhydrous facial oils and siloxane elixirs, Ascorbyl Tetraisopalmitate acts as the primary active. Dissolves instantly in squalane, caprylic/capric triglyceride, and hemisqualane without requiring co-solvents or heating, resulting in ultra-stable 2-year shelf life serums.
Dosage: 0.5% - 3.0%
In O/W and W/O creams, it should be pre-dissolved in the oil phase before emulsification. Compatible with anionic, non-ionic, and cationic emulsifier networks. Operates effectively across a neutral pH window (pH 5.0 - 7.0), avoiding skin irritation.
Dosage: 0.5% - 2.0%
Acts as a powerful singlet oxygen quencher when combined with UV filters like Bemotrizinol and DHHB. Reduces UV-induced lipid peroxidation in the stratum corneum and prevents sunscreen oil phase degradation under intense sunlight.
Dosage: 1.0% - 5.0%
Easily incorporates into molten wax bases (beeswax, carnauba, candelilla) at temperatures up to 75°C - 80°C. Delivers lip-lightening and anti-cheilitis benefits without changing the melting profile or texture of the stick product.
Ascorbyl Tetraisopalmitate delivers dramatically amplified performance when formulated alongside complementary oil-soluble actives:
In an volatile global chemical market, procurement officers and R&D directors require uninterrupted raw material supply, strict batch consistency, and transparent regulatory compliance. JIMPOCHEM CO., LTD operates at the heart of China's advanced chemical ecosystem, providing unmatched infrastructure and cost efficiency.
Our strategic location in Shandong Chemical Industry Park allows direct access to high-purity L-ascorbic acid and synthetic isopalmitic acid. Upstream integration protects our contract customers from global raw material price fluctuations and supply bottlenecks.
Featuring continuous-flow synthesis reactors paired with automated DCS (Distributed Control Systems), our plant achieves high batch-to-batch repeatability with annual Ascorbyl Tetraisopalmitate output exceeding multi-hundred metric tons.
We provide specialized packaging options ranging from 1kg aluminum bottles to 25kg / 200kg nitrogen-purged steel drums. Our export logistics team ensures full compliance with international maritime and air cargo regulations.
JIMPOCHEM CO., LTD was established in 2010 and is headquartered in the Chemical Industry Park of Jinan City, Shandong Province. The company covers an area of over 500 acres and is a professional chemical raw material manufacturer that integrates research and development, production, sales, and technical services. Its core focus is on high-end fine chemicals and cosmetic raw materials. We have obtained multiple product related certifications, including ISO quality system certification and environmental management system certification, and are committed to providing high-quality chemical products and one-stop procurement service solutions to global customers.
Our core team comprises experts with over 16 years of experience in the chemical industry. This enables us not only to provide professional products but also to offer solutions in product development, formula optimization, and supply chain management, meeting the personalized needs of diverse clients. We provide high-quality products and services, and our products are exported to over 200 countries and regions in Europe, America, Southeast Asia, the Middle East, and Oceania, serving more than 5,000 international companies. We have also established long-term strategic partnerships with many internationally renowned chemical companies, becoming a trusted "designated chemical service provider" for numerous clients.
Leveraging years of industry experience, we have established stable raw material procurement channels and partnered with top global chemical raw material suppliers, ensuring stable raw material quality and ample supply. Our modern production base employs an intelligent control system to automate and digitally manage the production process, balancing large-scale production with flexible customization needs.
Adhering to the philosophy that "quality is the lifeline of an enterprise," the company has established a comprehensive quality control system. From raw material warehousing and inspection, real-time monitoring of the production process, to full-item inspection of finished products before shipment, every step adheres to strict quality standards.
In response to the global "dual-carbon" strategy, the company focuses on the research and development and production of green chemical products, adopting environmentally friendly production processes and optimizing wastewater, waste gas, and waste residue treatment systems.
Navigating global cosmetic regulations is crucial for multinational brand success. Ascorbyl Tetraisopalmitate supplied by JIMPOCHEM satisfies regulatory frameworks across key international markets:
Fully listed on CosIng directory. Free of restricted heavy metal residues, residual solvents compliant with ICH Q3C guidelines, and non-animal tested (Cruelty-Free compliance).
Approved for inclusion in the Inventory of Existing Cosmetic Ingredients in China (IECIC). Low irritancy profile suitable for sensitive skin lines and post-dermatology care products.
Deemed safe as a cosmetic ingredient in present practices of use and concentration by the Cosmetic Ingredient Review (CIR) Expert Panel.
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