In the rapidly evolving landscape of advanced fine chemicals, cosmetic active intermediates, and targeted pharmaceutical precursors, CAS 10309-37-2 (chemically designated as 4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dienyl]phenol, widely recognized in commercial trade as high-purity Bakuchiol) represents a landmark meroterpene phenol compound. B2B procurement managers, technical formulation directors, and institutional buyers seeking to source high-purity CAS 10309-37-2 products require rigorous chemical data, verifiable analytical testing, and supply chain transparency to ensure formula stability and regulatory compliance.
| Analytical Parameter | Standard Commercial Specification | JIMPOCHEM Ultra-Pure Standard | Testing Methodology |
|---|---|---|---|
| Chemical Name | 4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dienyl]phenol / Bakuchiol | ||
| CAS Registry Number | 10309-37-2 | 10309-37-2 | CAS Index Verification |
| Molecular Formula / Mass | C18H24O / 256.38 g/mol | C18H24O / 256.38 g/mol | Mass Spectrometry (MS) |
| Appearance & State | Oily Liquid, Pale Yellow to Brown | Clear Light Yellowish Viscous Liquid | Visual Inspection |
| Assay Purity (HPLC) | ≥ 95.0% | ≥ 98.5% to 99.2% | High-Performance Liquid Chromatography |
| Heavy Metals (Pb, As, Cd, Hg) | < 10 ppm Total | < 2 ppm Ultra-Trace | ICP-MS Spectroscopy |
| Residual Solvents | Meets USP Limits | ND (Non-Detectable Benzene/Hexane) | GC-HS (Headspace Gas Chromatography) |
From a structural chemistry perspective, CAS 10309-37-2 possesses a unique monoterpene backbone fused with a phenolic ring. This configuration confers powerful anti-oxidative, anti-inflammatory, and retinoid-mimicking bioactivity without causing the cutaneous erythema or phototoxicity historically linked to conventional Vitamin A derivatives (Retinol). Consequently, international demand across North America, Europe, and Asia-Pacific has surged, positioning CAS 10309-37-2 as an indispensable active ingredient in next-generation anti-aging formulations, targeted dermatology solutions, and premium personal care products.
Regulatory tightening across the EU (REACH, SCCS) and the US FDA (MoCRA) has accelerated the phase-out of aggressive synthetic actives. Global cosmetic conglomerates are migrating toward naturally-derived, bio-compatible alternatives. CAS 10309-37-2 leads this transition, serving as a plant-derived, non-photosensitizing anti-aging benchmark.
Beyond cosmetic topical serums, academic research highlights CAS 10309-37-2’s efficacy in mitigating sebum peroxidation, suppressing Propionibacterium acnes growth, and modulating extracellular matrix degradation. This broadens procurement interest into dermatological therapeutics and specialty skincare.
Tier-1 global brands are abandoning unstable small-batch vendors in favor of large-scale, automated manufacturing facilities. Procurement intent prioritizes factory direct suppliers capable of delivering metric-ton quantities with lot-to-lot analytical consistency and complete audit trails.
Navigating global market volatility demands a robust manufacturing partner. China’s modern chemical infrastructure has evolved far beyond basic raw material processing into an automated, digitalized Industry 4.0 ecosystem. Manufacturers like JIMPOCHEM CO., LTD lead this transformation.
By integrating real-time Distributed Control Systems (DCS) and automated fractional distillation units, Chinese manufacturing hubs achieve precise thermoregulation and molecular separation during CAS 10309-37-2 processing. This eliminates thermal degradation, preventing isomer formation and ensuring an active assay consistently exceeding 98.5%.
Adhering strictly to ISO 9001 quality management and ISO 14001 environmental frameworks, every batch of CAS 10309-37-2 undergoes full-spectrum testing (HPLC, GC-MS, ICP-MS, Microbe verification). Downstream clients can trace raw material origins, operating temperatures, quality parameters, and shipping histories using unique batch barcodes.
In alignment with national "dual-carbon" sustainability strategies, state-of-the-art Chinese chemical parks implement advanced wastewater treatment facilities and closed-loop solvent recovery units. Purchasing CAS 10309-37-2 from compliant Chinese facilities protects buyers from environmental audit disruptions and regulatory supply halts.
Strategic proximity to major deep-water ports (Qingdao, Shanghai, Tianjin) combined with massive centralized manufacturing infrastructure allows Chinese suppliers to offer significant cost efficiency, customized barrier packaging (nitrogen-purged fluorinated drums), and reliable global delivery execution.
Formulating with CAS 10309-37-2 requires a clear understanding of its physical chemistry, lipid solubility, and oxidative sensitivity. As a meroterpene phenol, it exhibits excellent compatibility with oil phases, liposomal carriers, and synthetic ester bases.
Recommended dosage ranges from 0.5% to 1.0%. Soluble in caprylic/capric triglycerides, squalane, and plant oils. Incorporate during the cool-down phase (below 40°C) to maintain maximum therapeutic activity.
Exhibits dual therapeutic action: downregulates 5-alpha reductase and inhibits inflammatory cytokine release. Combines synergistically with N-Acetyl-D-Glucosamine (CAS 7512-17-6) or Zinc Pyrithione (CAS 13463-41-7).
Unlike Retinol, CAS 10309-37-2 does not induce photosensitivity. It acts as an auxiliary antioxidant, stabilizing broad-spectrum UV filters such as Bemotrizinol (CAS 187393-00-6) and enhancing overall photoprotective defense.
| Performance Parameter | CAS 10309-37-2 (High-Purity Bakuchiol) | Conventional Retinol (Vitamin A) | Formulation Impact |
|---|---|---|---|
| Photostability | Highly Stable under UV light | Degrades rapidly; requires dark packaging | CAS 10309-37-2 is suitable for daytime use |
| Skin Irritation Profile | Non-irritating, soothing, non-comedogenic | Frequent redness, scaling, dryness | Ideal for sensitive skin product lines |
| Collagen Stimulation | Upregulates Type I, III, IV Collagen | Upregulates Type I, III Collagen | Comparable anti-aging efficacy |
| Formulation Processing | Oil soluble; standard cold-mix phase | Requires strict oxygen-free handling | Significantly lower manufacturing risk |
Established in 2010 and headquartered in the prestigious Chemical Industry Park of Jinan City, Shandong Province, JIMPOCHEM CO., LTD operates an ultra-modern production footprint spanning over 500 acres. As an integrated chemical enterprise uniting advanced R&D, automated manufacturing, global sales, and ongoing technical support, JIMPOCHEM specializes in high-end fine chemicals, cosmetic actives, and fluorinated compounds.
Supported by a core team of senior chemical engineers and research scientists with over 16 years of hands-on experience, JIMPOCHEM delivers strategic formulation assistance, pilot-scale synthesis, and complete supply chain security tailored to global market specifications.
Exporting high-purity chemical raw materials to more than 200 countries and regions across North America, Europe, Southeast Asia, the Middle East, and Oceania, JIMPOCHEM proudly serves over 5,000 international corporate clients as a designated chemical service provider.
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